Cost-effectiveness analysis of molecular diagnosis by next-generation sequencing versus sequential single testing in metastatic non-small cell lung cancer patients from a south Spanish hospital perspective
| العنوان: | Cost-effectiveness analysis of molecular diagnosis by next-generation sequencing versus sequential single testing in metastatic non-small cell lung cancer patients from a south Spanish hospital perspective |
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| المؤلفون: | Enrique de Alava, María Jesús Pareja, David Carcedo, Natalia Arrabal, José-Francisco García, Reyes Bernabé-Caro |
| المساهمون: | Roche, Álava, Enrique de, Pareja, María Jesús, Carcedo, David, Bernabé Caro, Reyes |
| المصدر: | Expert Review of Pharmacoeconomics & Outcomes Research. 22:1033-1042 |
| بيانات النشر: | Informa UK Limited, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Lung Neoplasms, molecular profiling, Cost-Benefit Analysis, Health Policy, High-Throughput Nucleotide Sequencing, Non-small cell lung cancer (NSCLC), General Medicine, Sequential single testing, oncogenic drivers, Hospitals, Oncogenic drivers, Molecular profiling, Carcinoma, Non-Small-Cell Lung, sequential single testing, Mutation, Next-generation sequencing, Humans, Cost-effectiveness, next-generation sequencing, Pharmacology (medical), cost-effectiveness |
| الوصف: | [Background] To assess the cost-effectiveness of using next-generation sequencing (NGS) compared to sequential single-testing (SST) for molecular diagnostic and treatment of patients with advanced non-small cell lung cancer (NSCLC) from a Spanish single-center perspective, the Hospital Universitario Virgen del Rocio (HUVR). [Research design and methods] A decision-tree model was developed to assess the alterations detection alterations and diagnostic cost in patients with advanced NSCLC, comparing NGS versus SST. Model inputs such as testing, positivity rates, or treatment allocation were obtained from the literature and the clinical practice of HUVR experts through consultation. Several sensitivity analyses were performed to test the robustness of the model. [Results] Using NGS for molecular diagnosis of a 100-patients hypothetical cohort, 30 more alterations could be detected and 3 more patients could be enrolled in clinical-trials than using SST. On the other hand, diagnostic costs were increased up to €20,072 using NGS instead of SST. Using NGS time-to-results would be reduced from 16.7 to 9 days. [Conclusions] The implementation of NGS at HUVR for the diagnostic of patients with advanced NSCLC provides significant clinical benefits compared to SST in terms of alterations detected, treatment with targeted-therapies and clinical-trial enrollment, and could be considered a cost-effective strategy. This work was funded by Roche Farma S.A. |
| وصف الملف: | application/pdf |
| تدمد: | 1744-8379 1473-7167 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8c7d0c203940c20777587b060d91a43 https://doi.org/10.1080/14737167.2022.2078310 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d8c7d0c203940c20777587b060d91a43 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 17448379 14737167 |
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