Potential anti-EBV effects associated with elevated interleukin-21 levels: a case report
| العنوان: | Potential anti-EBV effects associated with elevated interleukin-21 levels: a case report |
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| المؤلفون: | Birgitte Preiss, Line D Rasmussen, Kristian Assing, Charlotte Brasch Andersen, Christian Nielsen, Kristin Skogstrand, Sussi Bagge Mortensen, Marianne Nielsine Skov, Shahin Gaïni, Marianne Antonius Jakobsen |
| المصدر: | BMC Infectious Diseases Assing, K, Nielsen, C, Jakobsen, M, Andersen, C B, Skogstrand, K, Gaini, S, Preiss, B, Mortensen, S B, Skov, M N & Rasmussen, L D 2020, ' Potential anti-EBV effects associated with elevated interleukin-21 levels : a case report ', BMC Infectious Diseases, vol. 20, 878 . https://doi.org/10.1186/s12879-020-05609-z |
| بيانات النشر: | BioMed Central, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, EBV disease, CD4-Positive T-Lymphocytes, Extracellular Space/metabolism, Epstein-Barr Virus Infections, Herpesvirus 4, Human, Herpesvirus 4, Human/genetics, Case Report, Plasma cell, CD8-Positive T-Lymphocytes, Lymphocyte Activation, Interleukin-21, Pneumococcal Vaccines, Interleukin 21, 0302 clinical medicine, Chronic active EBV infection, Germinal center, memory B cells, Interleukins/genetics, Memory B cell, B-Lymphocytes, Vaccination, B-Lymphocytes/immunology, T-Lymphocytes, Helper-Inducer, Infectious Diseases, medicine.anatomical_structure, CD4-Positive T-Lymphocytes/immunology, Female, T cell, Peripheral T follicular helper cells, CD4 T cells, Biology, Lymphocyte Activation/immunology, CD8-Positive T-Lymphocytes/immunology, 03 medical and health sciences, T-Lymphocytes, Helper-Inducer/immunology, Bcl-6, Case report, Pneumococcal Vaccines/immunology, medicine, Humans, B cell, Aged, Vaccines, Conjugate, Interleukins, Germinal center, medicine.disease, Epstein-Barr Virus Infections/genetics, 030104 developmental biology, Immunology, Mutation, Extracellular Space, CD8, 030215 immunology, Vaccines, Conjugate/immunology |
| الوصف: | Background Germinal center derived memory B cells and plasma cells constitute, in health and during EBV reactivation, the largest functional EBV reservoir. Hence, by reducing germinal center derived formation of memory B cells and plasma cells, EBV loads may be reduced. Animal and in-vitro models have shown that IL-21 can support memory B and plasma cell formation and thereby potentially contribute to EBV persistence. However, IL-21 also displays anti-viral effects, as mice models have shown that CD4+ T cell produced IL-21 is critical for the differentiation, function and survival of anti-viral CD8+ T cells able to contain chronic virus infections. Case presentation We present immunological work-up (flow-cytometry, ELISA and genetics) related to a patient suffering from a condition resembling B cell chronic active EBV infection, albeit with moderately elevated EBV copy numbers. No mutations in genes associated with EBV disease, common variable immunodeficiency or pertaining to the IL-21 signaling pathway (including hypermorphic IL-21 mutations) were found. Increased (> 5-fold increase 7 days post-vaccination) CD4+ T cell produced (p + lymphopenia, B lymphopenia, hypogammaglobulinemia, compromised memory B cell differentiation, absent induction of B-cell lymphoma 6 protein (Bcl-6) dependent peripheral follicular helper T cells (pTFH, p = 0.01), reduced frequencies of peripheral CD4+ Bcl-6+ T cells (p = 0.05), compromised plasmablast differentiation (reduced protein vaccine responses (p FH formation, pTFH and CD4+ IL-21+ frequencies were strongly inversely correlated, prior to and after vaccination, in the patient and in controls, Spearman’s rho: − 0.86, p Conclusions To the best of our knowledge, this is the first report of elevated CD4+ IL-21+ T cell frequencies in human EBV disease. IL-21 overproduction may, apart from driving T cell mediated anti-EBV responses, disrupt germinal center derived memory B cell and plasma cell formation, and thereby contribute to EBV disease control. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1471-2334 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e05fcd8cd161f04d975382fc6ff4f6 http://europepmc.org/articles/PMC7685648 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d8e05fcd8cd161f04d975382fc6ff4f6 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14712334 |
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