أعرض في EDS

Model-Based Patterns of Lymphedema Symptomatology: Phenotypic and Biomarker Characterization

التفاصيل البيبلوغرافية
العنوان: Model-Based Patterns of Lymphedema Symptomatology: Phenotypic and Biomarker Characterization
المؤلفون: Amber A. Guth, Jean Pierre Gagner, Deborah Axelrod, Bradley E. Aouizerat, Mei R. Fu, Jeanna M. Qiu, Gary Yu, David Zagzag, Yvette P. Conley
المصدر: Current breast cancer reports
بيانات النشر: Springer Science and Business Media LLC, 2020.
سنة النشر: 2020
مصطلحات موضوعية: Oncology, medicine.medical_specialty, VEGF receptors, Symptom, Article, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Surgical oncology, Latent class analysis, Internal medicine, medicine, Lymphedema, 030212 general & internal medicine, Limbvolume, Bioimpedance, biology, business.industry, medicine.disease, Phenotype, Latent class model, Symptom distress, 030220 oncology & carcinogenesis, biology.protein, Biomarker (medicine), Limb volume, business, Biomarkers
الوصف: Purpose of the Study More than 50% of breast cancer survivors without a diagnosis of lymphedema suffer daily from numerous and co-occurring lymphedema symptoms. This study aimed to identify lymphedema symptom patterns and the association of such patterns with phenotypic characteristics and biomarkers using latent class analysis (LCA). A prospective, descriptive, and repeated-measure design was used to enroll 140 women and collect data. Recent Findings LCA identified three distinct lymphedema symptom classes at 8 weeks and 12 months post-surgery: low, moderate, and severe symptom classes and associated phenotypic characteristics. Participants were more likely to be in the severe symptom classes at 12 months post-surgery if they had lower education level, cording, an axillary syndrome at 8 weeks post-surgery, neoadjuvant chemotherapy, and radiation. Summary Pre-surgery level of IL1-a, IL-6, IL-8, and VEGF was associated with the severe symptom class at 8 weeks post-surgery, suggesting that such biomarkers may be used to predict risk for lymphedema symptoms.
تدمد: 1943-4596
1943-4588
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8fa628a6a463352ae584b6f90fd81ef
https://doi.org/10.1007/s12609-020-00397-6
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....d8fa628a6a463352ae584b6f90fd81ef
قاعدة البيانات: OpenAIRE
الوصف
تدمد:19434596
19434588