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Plasmatic osteopontin and vascular access dysfunction in hemodialysis patients: a cross-sectional, case-control study (The OSMOSIS Study)

التفاصيل البيبلوغرافية
العنوان: Plasmatic osteopontin and vascular access dysfunction in hemodialysis patients: a cross-sectional, case-control study (The OSMOSIS Study)
المؤلفون: Sophie Bonnet, Joseph Carboni, Sandor Vido, Nathalie M. Mazure, Julie Contenti, Juliette Raffort, Christophe Koelsch, Philippe Gual, Serge Declemy, M Durand, Nirvana Sadaghianloo, Réda Hassen-Khodja
المساهمون: Centre méditerranéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)
المصدر: Journal of Nephrology
Journal of Nephrology, Italian Society of Nephrology/Springer, 2021, ⟨10.1007/s40620-021-01129-4⟩
سنة النشر: 2020
مصطلحات موضوعية: Nephrology, Male, medicine.medical_specialty, Osmosis, Intimal hyperplasia, Time Factors, [SDV]Life Sciences [q-bio], medicine.medical_treatment, 030232 urology & nephrology, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Arteriovenous Shunt, Surgical, Renal Dialysis, Internal medicine, Diabetes mellitus, medicine, Humans, ComputingMilieux_MISCELLANEOUS, Dialysis, Vascular Patency, Aged, Retrospective Studies, business.industry, Case-control study, medicine.disease, Thrombosis, 3. Good health, Stenosis, Cross-Sectional Studies, Treatment Outcome, Diabetes Mellitus, Type 2, Case-Control Studies, Cardiology, Osteopontin, Hemodialysis, business
الوصف: Despite close follow-up of patients with native arteriovenous fistulas (AVFs), up to 10% experience thrombosis each year. The OSMOSIS Study (Osteopontin as a Marker of Stenosis) tested the hypothesis that the systemic osteopontin level, a pro-inflammatory mediator related to vascular remodelling and intimal hyperplasia, increases in AVF stenosis, and may be used in clinical surveillance. Our cross-sectional study compared the level of plasmatic osteopontin (pOPN) between patients with a well-functioning AVF (control group) and patients who required revision of their AVF due to stenosis (stenosis group). Blood samples were collected before dialysis (control group) or before intervention (stenosis group) from the AVF arm, and from the opposite arm as a within-subject control. pOPN level was measured by enzyme-linked immunosorbent assay. A total of 76 patients were included in the study. Baseline characteristics were similar between the groups (mean age, 70 years; men, 63%; AVF duration, 39 months), apart from prevalence of type 2 diabetes (T2D) (control group, 33%; stenosis group, 57%; p = 0.04). pOPN levels were similar between the AVF arm and the contralateral arm (551 ± 42 ng/mL vs. 521 ± 41 ng/mL, respectively, p = 0.11, paired t-test). Patients in the stenosis group displayed a higher pOPN level than patients in the control group (650.2 ± 59.8 ng/mL vs. 460.5 ± 61.2, respectively, p = 0.03; two-way ANOVA). T2D was not identified as an associated factor in a multivariate analysis (p = 0.50). The level of pOPN in hemodialysis patients was associated with the presence of AVF stenosis requiring intervention. Thus, its potential as a diagnostic biomarker should be assessed in a vascular access surveillance program.
تدمد: 1724-6059
1121-8428
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9734e390789941bbba35cd37fe9079d
https://pubmed.ncbi.nlm.nih.gov/34468976
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....d9734e390789941bbba35cd37fe9079d
قاعدة البيانات: OpenAIRE
الوصف
تدمد:17246059
11218428