VTX‐1 Liquid Biopsy System for Fully‐Automated and Label‐Free Isolation of Circulating Tumor Cells with Automated Enumeration by BioView Platform
| العنوان: | VTX‐1 Liquid Biopsy System for Fully‐Automated and Label‐Free Isolation of Circulating Tumor Cells with Automated Enumeration by BioView Platform |
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| المؤلفون: | Elodie Sollier-Christen, Steve C. Crouse, Tal Kaplan, Elad Kfir, Corinne Renier |
| المصدر: | Cytometry |
| بيانات النشر: | Wiley, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Histology, Isolation (health care), microfluidics, Cell Count, Cell Separation, Computational biology, circulating tumor cells, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, Circulating tumor cell, Cell Line, Tumor, Neoplasms, Enumeration, Humans, Medicine, Liquid biopsy, Vortex technology, Label free, Automation, Laboratory, Staining and Labeling, liquid biopsy, business.industry, Original Articles, Cell Biology, Neoplastic Cells, Circulating, Biomarker (cell), 030104 developmental biology, Fully automated, 030220 oncology & carcinogenesis, Original Article, business, Cytometry |
| الوصف: | Clinicians continue to rely on invasive tissue biopsies as a mean to assess a patient's disease and prescribe appropriate treatment regimens. Biopsies not only are risky and expensive but also limit the understanding of disease. Circulating tumor cells (CTCs) can be isolated from a simple blood draw and offer a promising potential to both diagnose and monitor cancer progression. The VTX‐1 Liquid Biopsy System automates the isolation of clinically relevant CTC populations, while simplifying their collection for easy analysis, ultimately expanding the clinical possibilities for CTCs. We present here the key features and performance of this automated system for isolating CTCs directly from whole blood, both with cell spiking experiments and patient samples. As a first step toward the characterization of CTCs for research applications and transfer to clinical practice, we present workflows for both molecular analyses and automated cell enumeration and biomarker quantification with the BioView imaging platform. © 2018 The Authors. Cytometry Part A published by Wiley Periodicals, Inc. on behalf of International Society for Advancement of Cytometry. |
| تدمد: | 1552-4930 1552-4922 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9956dc9c689bd7cd9d5afd2cbb87af0 https://doi.org/10.1002/cyto.a.23592 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d9956dc9c689bd7cd9d5afd2cbb87af0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15524930 15524922 |
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