Biases in human papillomavirus genotype prevalence assessment associatedwith commonly used consensus primers
| العنوان: | Biases in human papillomavirus genotype prevalence assessment associatedwith commonly used consensus primers |
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| المؤلفون: | Jo L.K. Cheung, Mamie Hui, Tak Hong Cheung, Ann O. Y. Tam, Margaret Ip, May M.Y. Yu, Keith W.K. Lo, Ka Fai To, Paul K.S. Chan, So Fan Yim, Yick Fu Wong, Denise P. C. Chan |
| المصدر: | International Journal of Cancer. 118:243-245 |
| بيانات النشر: | Wiley, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Cancer Research, medicine.medical_specialty, Genotype, Uterine Cervical Neoplasms, Cancer Vaccines, Sensitivity and Specificity, Virus, law.invention, law, Epidemiology, Prevalence, medicine, Humans, Papillomaviridae, Polymerase chain reaction, DNA Primers, Cervical cancer, business.industry, Papillomavirus Infections, Reproducibility of Results, Consensus primer, medicine.disease, Virology, Oncology, Carcinoma, Squamous Cell, Female, Viral disease, Primer (molecular biology), business |
| الوصف: | Consensus primers targeting human papillomaviruses (HPVs) have biases in sensitivity toward certain HPV types. We applied 3 primer sets (GP5+/6+, MY09/11, PGMY09/11) in parallel on 120 Chinese cervical cancer specimens. GP5+/6+ exhibited a poor sensitivity for HPV52, for which the prevalence among squamous cell cervical cancer was underestimated from 14.6% to 0%. The fact that HPV52 should rank second in prevalence among squamous cell cervical carcinoma in Hong Kong could be missed if GP5+/6+, a worldwide commonly used primer set, was selected for HPV detection. Biases in HPV type-specific sensitivity may result in misprioritization of vaccine candidates. |
| تدمد: | 1097-0215 0020-7136 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d99fd5d92752e779d22d9fe43947b9ce https://doi.org/10.1002/ijc.21299 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d99fd5d92752e779d22d9fe43947b9ce |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970215 00207136 |
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