Total-Body 68Ga-PSMA-11 PET/CT for Bone Metastasis Detection in Prostate Cancer Patients: Potential Impact on Bone Scan Guidelines
| العنوان: | Total-Body 68Ga-PSMA-11 PET/CT for Bone Metastasis Detection in Prostate Cancer Patients: Potential Impact on Bone Scan Guidelines |
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| المؤلفون: | Tristan Grogan, Wesley R Armstrong, John W Williams, Jeremie Calais, Johannes Czernin, Kelsey L. Pomykala |
| المصدر: | Journal of nuclear medicine : official publication, Society of Nuclear Medicine, vol 61, iss 3 |
| بيانات النشر: | Society of Nuclear Medicine, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Image Processing, urologic and male genital diseases, 030218 nuclear medicine & medical imaging, Prostate cancer, Computer-Assisted, 0302 clinical medicine, Positron Emission Tomography Computed Tomography, 80 and over, 2.1 Biological and endogenous factors, guidelines, Aetiology, Prospective cohort study, Gallium Isotopes, bone metastasis, Cancer, Prostate Cancer, Incidence (epidemiology), Bone metastasis, Middle Aged, Nuclear Medicine & Medical Imaging, 030220 oncology & carcinogenesis, Practice Guidelines as Topic, Biomedical Imaging, field of view, Oligopeptides, Whole-Body Irradiation, Adult, Urologic Diseases, Biochemical recurrence, PET/CT, Clinical Sciences, Bone Neoplasms, Gallium Radioisotopes, Bone and Bones, 03 medical and health sciences, PSMA, medicine, Humans, Radiology, Nuclear Medicine and imaging, Femur, Edetic Acid, Retrospective Studies, Aged, PET-CT, business.industry, Prevention, Prostatic Neoplasms, medicine.disease, business, Nuclear medicine |
| الوصف: | Our purpose was to determine the relationship between serum prostate-specific antigen (PSA) level categories (20 ng/mL) and the incidence of bone metastases detected by total-body 68Ga-prostate-specific membrane antigen (PSMA)-11 PET/CT and to assess if expanding the 68Ga-PSMA-11 PET/CT imaging field to include the vertex and lower extremities (total-body acquisition) affects bone metastasis detection rates and patient management. Methods: This was a retrospective analysis of 388 prostate cancer patients enrolled in 5 prospective studies (NCT02940262, NCT03368547, NCT03042312, NCT04050215, and NCT03515577). All underwent 68Ga-PSMA-11 PET/CT scans acquired from vertex to toes for primary staging (n = 93/388, 24%), biochemical recurrence (BCR) localization (n = 225/388, 58%), or restaging metastatic disease (M1) before or during systemic therapy (n = 70/388, 18%) between September 2017 and May 2018. Results: In total, 321 of 388 patients (83%) had a positive 68Ga-PSMA-11 study. PSMA-positive bone lesions were found in 105 of 388 (27%) patients, with an incidence that was positively associated with serum PSA level ( |
| وصف الملف: | application/pdf |
| تدمد: | 2159-662X 0161-5505 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9c312bc5446905bb752b013be92f0a7 https://doi.org/10.2967/jnumed.119.230318 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d9c312bc5446905bb752b013be92f0a7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2159662X 01615505 |
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