Buccal fat pad‐derived stem cells with anorganic bovine bone mineral scaffold for augmentation of atrophic posterior mandible: An exploratory prospective clinical study
| العنوان: | Buccal fat pad‐derived stem cells with anorganic bovine bone mineral scaffold for augmentation of atrophic posterior mandible: An exploratory prospective clinical study |
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| المؤلفون: | Homayoun H. Zadeh, Sepanta Hosseinpour, Maryam Rezai Rad, Marzieh Alikhasi, Arash Khojasteh |
| المصدر: | Clinical Implant Dentistry and Related Research. 21:292-300 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Scaffold, Cone beam computed tomography, 0206 medical engineering, Dentistry, Mandible, 02 engineering and technology, 03 medical and health sciences, 0302 clinical medicine, Tissue engineering, Alveolar ridge, Animals, Humans, Medicine, Prospective Studies, General Dentistry, Minerals, Buccal fat pad, Bone Transplantation, business.industry, Stem Cells, Dental Implantation, Endosseous, Alveolar Ridge Augmentation, 030206 dentistry, Buccal administration, 020601 biomedical engineering, Adipose Tissue, Cattle, Oral Surgery, Stem cell, business |
| الوصف: | Background Application of adipose-derived stem cells originated from buccal fat pad (BFP) can simplify surgical procedures and diminish clinical risks compared to large autograft harvesting. Purpose This study sought to evaluate and compare the efficacy of buccal fat pad-derived stem cells (BFPSCs) in combination with anorganic bovine bone mineral (ABBM) for vertical and horizontal augmentation of atrophic posterior mandibles. Materials and methods Fourteen patients with atrophic posterior mandible were elected for this prospective exploratory study. BFP (3-5 mL) was harvested and BFPSCs were isolated and combined with ABBM at 50% ratio. The vertical and horizontal alveolar deficiencies were augmented by 50% mixture of ABBM with either BFPSCs (group 1) or particulated autologous bone (group 2). Titanium mesh was contoured to the desired 3D shape of the alveolar ridge and fixated to the host sites over the graft material of the two groups. At first, the amount of new bone areas was calculated by quantitative analysis of cone beam computed tomography (CBCT) images that were taken 6 months postoperatively according to regenerative techniques (group 1 vs group 2 without considering the type of bone defects). Second, these amounts were calculated in each group based on the type of defects. Results Quantitative analysis of CBCT images revealed the areas of new bone formation were 169.5 ± 5.90 mm2 and 166.75 ± 10.05 mm2 in groups 1 and 2, respectively. The area of new bone formation for vertical defects were 164.91 ± 3.74 mm2 and 169.36 ± 12.09 mm2 in groups 1 and 2, respectively. The area of new bone formation for horizontal deficiencies were 170.51 ± 4.54 mm2 and 166.98 ± 9.36 mm2 in groups 1 and 2, respectively. There were no statistically significant differences between the two groups in any of the pair-wise comparisons (P > 0.05). Conclusions The findings of the present study demonstrated lack of difference in bone volume formation between BFPSCs and autologous particulate bone in combination with ABBM. If confirmed by future large-scale clinical trial, BFPSCs may provide an alternative to autogenous bone for reconstruction of alveolar ridge defects. |
| تدمد: | 1708-8208 1523-0899 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e676e65dcf1f30b3e1747604bf1497 https://doi.org/10.1111/cid.12729 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....d9e676e65dcf1f30b3e1747604bf1497 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17088208 15230899 |
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