A rare cause of severe Cushing’s syndrome
| العنوان: | A rare cause of severe Cushing’s syndrome |
|---|---|
| المؤلفون: | Wernig, F, Zaman, S, Patel, B, Glynne, P, Vanderpump, M, Alsafi, A, Khan, S, Flora, R, Palazzo, F |
| المصدر: | Endocrinology, Diabetes & Metabolism Case Reports, Vol 1, Iss 1, Pp 1-5 (2020) Endocrinology, Diabetes & Metabolism Case Reports |
| بيانات النشر: | BioScientifica, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Ventricular hypertrophy, Anticoagulants, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Echocardiogram, Cushing's syndrome, Laparoscopic adrenalectomy, White, Gastroenterology, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Haematoxylin and eosin staining, Cortisol, Beta-blockers, 0302 clinical medicine, Metanephrines, Diabetes mellitus type 1, Antibiotics, Hyperpigmentation, Palpitations, Co-trimoxazole, Hyperglycaemia, Insulin, Adrenal, Vitamin D, Tremulousness, Hypokalaemia, Adrenalectomy, Arthralgia, Propranolol, Diarrhoea, Normetanephrine, 030220 oncology & carcinogenesis, Potassium chloride, Hypertension, Prednisolone, Vomiting, Blood pressure, medicine.symptom, medicine.drug, Dexamethasone suppression, Insight into disease pathogenesis or mechanism of therapy, Adult, CT scan, medicine.medical_specialty, Heart rate, Metanephrines (plasma), Cardiology, Histopathology, 030209 endocrinology & metabolism, Glucose (blood), 03 medical and health sciences, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Glucocorticoids, Weight gain, lcsh:RC648-665, Metyrapone, March, Phenoxybenzamine, business.industry, Hypercortisolaemia, Phaeochromocytoma, medicine.disease, Cortisol (serum), Hyperactivity, United Kingdom, ACTH, Potassium, Alpha-blockers, Calcium, Amlodipine, business, Resection of tumour, Malaise, Catecholamines (plasma) |
| الوصف: | Summary Ectopic adrenocorticotropic hormone (ACTH) production is an uncommon cause of Cushing’s syndrome and, rarely, the source can be a phaeochromocytoma. A 55-year-old man presented following an episode of presumed gastroenteritis with vomiting and general malaise. Further episodes of diarrhoea, joint pains and palpitations followed. On examination, he was hypertensive with no clinical features to suggest hypercortisolaemia. He was subsequently found to have raised plasma normetanephrines of 3.98 nmol/L (NR Learning points: Phaeochromocytomas are a rare source of ectopic ACTH secretion. A high clinical index of suspicion is therefore required to make the diagnosis. Ectopic ACTH secretion from a phaeochromocytoma can rapidly progress to severe Cushing’s syndrome, thus complicating tumour removal. Removal of the primary tumour often leads to full recovery. The limited literature suggests that the presence of ectopic Cushing’s syndrome does not appear to have any long-term prognostic implications. |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da139ddb04c47ffdfabcb7f72a4bc701 http://hdl.handle.net/10044/1/78126 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....da139ddb04c47ffdfabcb7f72a4bc701 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |