Stereoselective Diversity-Oriented Solution and Solid-Phase Synthesis of Tetrahydroquinoline-Based Polycyclic Derivatives
| العنوان: | Stereoselective Diversity-Oriented Solution and Solid-Phase Synthesis of Tetrahydroquinoline-Based Polycyclic Derivatives |
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| المؤلفون: | Reni Joseph, Patricia Durieux, Donald M. Leek, Prabhat Arya, Zai-Xin Chen |
| المصدر: | Journal of Combinatorial Chemistry. 6:54-64 |
| بيانات النشر: | American Chemical Society (ACS), 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | Spectrometry, Mass, Electrospray Ionization, Magnetic Resonance Spectroscopy, Bicyclic molecule, Chemistry, Stereoisomerism, Borohydrides, General Chemistry, Solution synthesis, Metathesis, Combinatorial chemistry, Solutions, Enantiopure drug, Solid-phase synthesis, Lithium Compounds, Quinolines, Michael reaction, Organic chemistry, Indicators and Reagents, Polycyclic Compounds, Stereoselectivity |
| الوصف: | A diversity-oriented solution and solid-phase synthesis of tetrahydroquinoline-based tricyclic derivatives has been achieved from enantiomerically pure, natural product-like bicyclic scaffold. The solution synthesis of enantiopure bicyclic scaffold was developed by asymmetric hetero Michael reaction. Our approach for the synthesis of polycyclic derivatives utilized regio- and stereoselective hetero Michael reaction and ring-closing metathesis as key steps in solution and on solid phase. |
| وصف الملف: | application/pdf |
| تدمد: | 1520-4774 1520-4766 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da5e294169544e585714beb22dba405d https://doi.org/10.1021/cc034053z |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....da5e294169544e585714beb22dba405d |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15204774 15204766 |
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