Caviar Extract and Its Constituent DHA Inhibits UVB-Irradiated Skin Aging by Inducing Adiponectin Production
| العنوان: | Caviar Extract and Its Constituent DHA Inhibits UVB-Irradiated Skin Aging by Inducing Adiponectin Production |
|---|---|
| المؤلفون: | Seunghyun Kang, Sung-Min Park, Hyeonju Yeo, Youn-Hwa Nho, Kyung-Eun Lee, Seok Kyun Yun |
| المصدر: | International Journal of Molecular Sciences Volume 21 Issue 9 International Journal of Molecular Sciences, Vol 21, Iss 3383, p 3383 (2020) |
| بيانات النشر: | MDPI, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Eggs, Gene Expression, Matrix metalloproteinase, Skin Aging, lcsh:Chemistry, chemistry.chemical_compound, Mice, Adipocyte, Adipocytes, lcsh:QH301-705.5, Spectroscopy, adipocyte differentiation, MMP, Cell Differentiation, General Medicine, Computer Science Applications, DHA, medicine.anatomical_structure, Docosahexaenoic acid, Matrix Metalloproteinase 1, caviar extract, medicine.medical_specialty, Docosahexaenoic Acids, Ultraviolet Rays, Foreskin, Phospholipid, Catalysis, Article, Cell Line, Inorganic Chemistry, Dermis, Internal medicine, 3T3-L1 Cells, Fish Products, medicine, Animals, Humans, Physical and Theoretical Chemistry, Molecular Biology, Transcription factor, Adiponectin, adiponectin, Organic Chemistry, Fibroblasts, Endocrinology, chemistry, lcsh:Biology (General), lcsh:QD1-999 |
| الوصف: | In this study, caviar (sturgeon eggs) was used to elucidate its roles in adiponectin production and skin anti-aging. Recently, caviar has been largely used not only as a nutritional food, but also in cosmetic products. In particular, it has been reported that docosahexaenoic acid (DHA), as one of the main phospholipid components of caviar extract, induces intracellular lipid accumulation and the expression of adiponectin in adipocytes. Although adipocytes are well known to be associated with the skin dermis by secreting various factors (e.g., adiponectin), the effects of caviar extract and DHA on the skin are not well studied. Here, we demonstrate the effects of caviar extract and DHA on adipocyte differentiation and adiponectin production, resulting in a preventive role in UV-irradiated skin aging. Caviar extract and DHA enhanced adipocyte differentiation and promoted the synthesis of transcription factors controlling adipocyte differentiation and adiponectin. In addition, the mRNA expression levels of matrix metalloproteinase-1 (MMP-1) were decreased in UVB-irradiated Hs68 fibroblasts that were cultured in conditioned medium from caviar extract or DHA-treated differentiated adipocytes. Taken together, these results indicate that caviar extract and DHA induce adipocyte differentiation and adiponectin production, thereby inhibiting UVB-induced premature skin aging via the suppression of MMP-1 production. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1422-0067 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da86cf511cc7c5b5c728b79a12b5d9f3 http://europepmc.org/articles/PMC7246982 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....da86cf511cc7c5b5c728b79a12b5d9f3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
|---|