Periodic MRI Lung Volume Assessment in Fetuses With Congenital Diaphragmatic Hernia: Prediction of Survival, Need for ECMO, and Development of Chronic Lung Disease
| العنوان: | Periodic MRI Lung Volume Assessment in Fetuses With Congenital Diaphragmatic Hernia: Prediction of Survival, Need for ECMO, and Development of Chronic Lung Disease |
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| المؤلفون: | Christel Weiss, K. Wolfgang Neff, Stefan O. Schönberg, KA Büsing, Angelika Debus, Anna Walleyo, Sven Kehl, Thomas Schaible |
| المصدر: | American Journal of Roentgenology. 201:419-426 |
| بيانات النشر: | American Roentgen Ray Society, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Lung Diseases, Male, medicine.medical_specialty, medicine.medical_treatment, Context (language use), Severity of Illness Index, Extracorporeal Membrane Oxygenation, Predictive Value of Tests, Pregnancy, medicine, Extracorporeal membrane oxygenation, Humans, Radiology, Nuclear Medicine and imaging, Lung volumes, Hernia, Diaphragmatic, Fetus, Chi-Square Distribution, Receiver operating characteristic, business.industry, Incidence (epidemiology), Infant, Newborn, Congenital diaphragmatic hernia, General Medicine, medicine.disease, Magnetic Resonance Imaging, Surgery, Survival Rate, Logistic Models, ROC Curve, Area Under Curve, Gestation, Female, Radiology, Hernias, Diaphragmatic, Congenital, Lung Volume Measurements, business |
| الوصف: | The purpose of the study was to investigate the ability to predict survival, need for extracorporeal membrane oxygenation (ECMO), and incidence of chronic lung disease in patients with congenital diaphragmatic hernia in the context of a classification into three different times of gestation (28, 28-32, and32 weeks) by assessing the ratio between observed and expected MRI fetal lung volume.The data analysis included 226 fetuses with congenital diaphragmatic hernia. MRI was performed at different times of gestation with a T2-weighted HASTE sequence. Receiver operating characteristic curve analysis was performed to investigate the prognostic value of assessment of the ratio between observed and expected MRI fetal lung volumes at different stages of fetal growth.For all reviewed times of gestation, the ratio between observed and expected MRI fetal lung volumes had almost equivalent statistically significant differences for neonatal survival (p ≤ 0.0029), need for ECMO therapy (p ≤ 0.0195), and development of chronic lung disease (p ≤ 0.0064). Results with high prognostic accuracy for early and for medium and late times in gestation also were obtained. Receiver operating characteristic analysis showed the highest area under the curve (≥ 0.819) for neonatal survival.In patients with congenital diaphragmatic hernia, the relation between observed and expected MRI fetal lung volume is a valuable prognostic parameter for predicting neonatal mortality, morbidity represented by the development of chronic lung disease, and the need for ECMO therapy in early gestation (28 weeks) as well as later gestation with no statistically significant differences. |
| تدمد: | 1546-3141 0361-803X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8e2f79999536eb0d72a3f490dfc48b https://doi.org/10.2214/ajr.12.8655 |
| رقم الأكسشن: | edsair.doi.dedup.....da8e2f79999536eb0d72a3f490dfc48b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15463141 0361803X |
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