Chitosan/PEGDA based scaffolds as bioinspired materials to control in vitro angiogenesis
| العنوان: | Chitosan/PEGDA based scaffolds as bioinspired materials to control in vitro angiogenesis |
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| المؤلفون: | Alessandra Soriente, Luigi Ambrosio, Christian Demitri, Elisabeth Engel, Ines Fasolino, Maria Grazia Raucci, Soledad Pérez Amodio |
| المساهمون: | Universitat Politècnica de Catalunya. Departament de Ciència i Enginyeria de Materials, Universitat Politècnica de Catalunya. IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies, Soriente, A., Amodio, S. P., Fasolino, I., Raucci, M. G., Demitri, C., Engel, E., Ambrosio, L. |
| المصدر: | UPCommons. Portal del coneixement obert de la UPC Universitat Politècnica de Catalunya (UPC) |
| بيانات النشر: | Elsevier BV, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Chitosan/PEGDA based scaffolds, Materials science, Human umbilical vein endothelial cells HUVECs, Angiogenesis, Neovascularization, Physiologic, Bioengineering, 02 engineering and technology, Enginyeria dels materials [Àrees temàtiques de la UPC], 010402 general chemistry, 01 natural sciences, Regenerative medicine, Umbilical vein, Polyethylene Glycols, Human umbilical vein endothelial cells HUVEC, Biomaterials, Chitosan, Neovascularization, chemistry.chemical_compound, Osteogenesis, Human Umbilical Vein Endothelial Cells, medicine, Humans, BMP-2 peptide, Tube formation, Tissue Engineering, Tissue Scaffolds, Cell growth, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Cell biology, Angiogenesi, Durapatite, chemistry, Chitosan/PEGDA based scaffold, Materials biomèdics, Mechanics of Materials, medicine.symptom, 0210 nano-technology, Biomedical materials, Ethylene glycol |
| الوصف: | In the current work, our purpose was based on the assessment of bioactive chitosan (CS)/Poly(ethylene glycol) diacrylate (PEGDA) based scaffolds ability to stimulate in vitro angiogenesis process. The bioactivation of the scaffolds was accomplished by using organic (BMP-2 peptide) and inorganic (hydroxyapatite nanoparticles) cues. In particular, the properties of the materials in terms of biological response promotion on human umbilical vein endothelial cells (HUVECs) were studied by using in vitro angiogenesis tests based on cell growth and proliferation. Furthermore, our interest was to examine the scaffolds capability to modulate two important steps involved in angiogenesis process: migration and tube formation of cells. Our data underlined that bioactive signals on CS/PEGDA scaffolds surface induce a desirable effect on angiogenic response concerning angiogenic marker expression (CD-31) and endothelial tissue formation (tube formation). Taken together, the results emphasized the concept that bioactive CS/PEGDA scaffolds may be novel implants for stimulating neovascularization of tissue-engineered constructs in regenerative medicine field. |
| وصف الملف: | application/pdf; ELETTRONICO |
| تدمد: | 0928-4931 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da9c94ace986d452c428d47f905e92db https://doi.org/10.1016/j.msec.2020.111420 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....da9c94ace986d452c428d47f905e92db |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09284931 |
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