Background and objectives: Polycystic ovarian syndrome or PCOS is recognized as one of the most prevalent endocrine conditions that affect a considerable proportion of women of reproductive age. The main objective of the study is to analyze the effect of Metformin in polycystic ovarian syndrome in local female population of Pakistan. Materials and Methods: This descriptive study was conducted at Jinnah Hospital, Lahore from June 2019 to January 2020. Women at or above 18 years of age, with an upper limit of thosewho have not undergone menopause, were included in the study. It was particularly ascertained from patient records that each participant has had a clinical diagnosis of PCOS from the hospital and has been using metformin as per a doctor’s prescription. Results: The data consist of 50 patients. The mean age of the study participants was 27.2 ± 4.75 years. All the participants were residents of Lahore. The ratio of married to unmarried patients was 1.7:1. Conclusion: It is concluded that Metformin has been realized to have a significant role in relieving the symptoms ofpolycystic ovarian syndrome.