Assessing spatial resolution, acquisition time and signal-to-noise ratio for commercial microimaging systems at 14.1, 17.6 and 22.3 T
| العنوان: | Assessing spatial resolution, acquisition time and signal-to-noise ratio for commercial microimaging systems at 14.1, 17.6 and 22.3 T |
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| المؤلفون: | Andrew G. Webb, Huub J. M. de Groot, A. Alia, Julia R. Krug, Aldrik H. Velders, Henk Van As, Frank J. Vergeldt, Remco van Schadewijk |
| المصدر: | Journal of Magnetic Resonance Journal of Magnetic Resonance 316 (2020) Journal of Magnetic Resonance, 316. ACADEMIC PRESS INC ELSEVIER SCIENCE Journal of Magnetic Resonance, 316, 106770 Journal of Magnetic Resonance, 316 |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Nuclear and High Energy Physics, Field (physics), Limit of detection, Biophysics, 010402 general chemistry, 01 natural sciences, Biochemistry, Signal, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Acceleration, 0302 clinical medicine, Optics, Ultra-high field strength, Magnetic resonance microscopy, Spectroscopy, Image resolution, BioNanoTechnology, VLAG, Physics, business.industry, Condensed Matter Physics, 0104 chemical sciences, Magnetic field, Biofysica, Signal-to-noise ratio (imaging), Signal-to-noise ratio, EPS, business |
| الوصف: | This work provides a systematic comparison of the signal-to-noise ratio (SNR), spatial resolution, acquisition time and metabolite limits-of-detection for magnetic resonance microscopy and spectroscopy at three different magnetic field strengths of 14.1 T, 17.6 T and 22.3 T (the highest currently available for imaging), utilizing commercially available hardware. We find an SNR increase of a factor 5.9 going from 14.1 T to 22.3 T using 5 mm radiofrequency (saddle and birdcage) coils, which results in a 24-fold acceleration in acquisition time and deviates from the theoretically expected increase of factor 2.2 due to differences in hardware. This underlines the importance of not only the magnetic field strengths but also hardware optimization. In addition, using a home-built 1.5 mm solenoid coil, we can achieve an isotropic resolution of (5.5 mu m)(3) over a field-of-view of 1.58 mm x 1.05 mm x 1.05 mm with an SNR of 12:1 using 44 signal averages in 58 h 34 min acquisition time at 22.3 T. In light of these results, we discuss future perspectives for ultra-high field Magnetic Resonance Microscopy and Spectroscopy. (C) 2020 The Authors. Published by Elsevier Inc. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1090-7807 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daaedbc783d0e50514ab093e10a3acb1 https://doi.org/10.1016/j.jmr.2020.106770 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....daaedbc783d0e50514ab093e10a3acb1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10907807 |
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