Evaluation and Comparison of Serological Methods for COVID-19 Diagnosis
| العنوان: | Evaluation and Comparison of Serological Methods for COVID-19 Diagnosis |
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| المؤلفون: | Bofeng Li, Liu Liu, Hua-xing Wei, Qiangsheng Li, Fanwu Gong |
| المصدر: | Frontiers in Molecular Biosciences Frontiers in Molecular Biosciences, Vol 8 (2021) |
| بيانات النشر: | Frontiers Media SA, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, COVID-19 diagnosis, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), QH301-705.5, Review, serological testing, Biochemistry, Genetics and Molecular Biology (miscellaneous), Biochemistry, Serology, 03 medical and health sciences, 0302 clinical medicine, antibody, Medicine, Molecular Biosciences, 030212 general & internal medicine, Biology (General), Intensive care medicine, Molecular Biology, medicine.diagnostic_test, SARS-CoV-2, business.industry, Nucleic acid test, LFIA, Virus detection, 030104 developmental biology, Clinical diagnosis, ELISA, Lower cost, business, Nucleic acid detection, Lateral flow immunoassay |
| الوصف: | The worldwide pandemic of COVID-19 has become a global public health crisis. Various clinical diagnosis methods have been developed to distinguish COVID-19–infected patients from healthy people. The nucleic acid test is the golden standard for virus detection as it is suitable for early diagnosis. However, due to the low amount of viral nucleic acid in the respiratory tract, the sensitivity of nucleic acid detection is unsatisfactory. As a result, serological screening began to be widely used with the merits of simple procedures, lower cost, and shorter detection time. Serological tests currently include the enzyme-linked immunosorbent assay (ELISA), lateral flow immunoassay (LFIA), and chemiluminescence immunoassay (CLIA). This review describes various serological methods, discusses the performance and diagnostic effects of different methods, and points out the problems and the direction of optimization, to improve the efficiency of clinical diagnosis. These increasingly sophisticated and diverse serological diagnostic technologies will help human beings to control the spread of COVID-19. |
| تدمد: | 2296-889X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1a162c8ab4a5347d7e7c777935617e https://doi.org/10.3389/fmolb.2021.682405 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....db1a162c8ab4a5347d7e7c777935617e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2296889X |
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