Predictive Utility of Type and Duration of Symptoms at Initial Presentation in Patients with Mild Cognitive Impairment
| العنوان: | Predictive Utility of Type and Duration of Symptoms at Initial Presentation in Patients with Mild Cognitive Impairment |
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| المؤلفون: | Patrick J. Brown, Deidre J. Devier, Nicole R. Villemarette-Pittman, Yaakov Stern, Gregory H. Pelton, Devangere P. Devanand, Mary Sano |
| المصدر: | Dementia and Geriatric Cognitive Disorders. 30:238-244 |
| بيانات النشر: | S. Karger AG, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Cognitive Neuroscience, Neuropsychological Tests, Audiology, Developmental psychology, Central nervous system disease, Cognition, Alzheimer Disease, Predictive Value of Tests, medicine, Humans, Original Research Article, Neuropsychological assessment, Depression (differential diagnoses), Aged, Proportional Hazards Models, Aged, 80 and over, medicine.diagnostic_test, Proportional hazards model, Cognitive disorder, Middle Aged, medicine.disease, Psychiatry and Mental health, Predictive value of tests, Disease Progression, Female, Geriatrics and Gerontology, Alzheimer's disease, Cognition Disorders, Psychology |
| الوصف: | Background/Aims: To assess (1) the duration and symptoms present in participants with mild cognitive impairment (MCI) and (2) the impact of these variables on predicting conversion to Alzheimer’s disease (AD). Methods: Participants with MCI (n = 148) were assessed and followed systematically. Results: Decline in memory was reported as the first symptom in 118 of the cases. Converters had more symptoms (e.g. language decline, depression), and the combination of decline in memory and in performance of high-order social/cognitive activities as well as disorientation more often than nonconverters (p = 0.036). In an age-stratified Cox model, predictors of conversion to AD were shorter time since onset of memory decline and lower baseline MMSE score. Conclusions: Recent onset of memory decline with older age, decreased MMSE score, change in performance and disorientation indicate a greater likelihood of short-term conversion to AD. |
| تدمد: | 1421-9824 1420-8008 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db5187e2206180122ea933a9da04c898 https://doi.org/10.1159/000320137 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....db5187e2206180122ea933a9da04c898 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14219824 14208008 |
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