African 2, a Clonal Complex of Mycobacterium bovis Epidemiologically Important in East Africa
| العنوان: | African 2, a Clonal Complex of Mycobacterium bovis Epidemiologically Important in East Africa |
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| المؤلفون: | Abraham Aseffa, Rudovick Kazwala, Markus Hilty, Simeon Cadmus, Gunilla Källenius, Moses Joloba, Rebuma Firdessa, Jakob Zinsstag, Adelina Machado, Stefan Berg, Kristin Kremer, Dick van Soolingen, Custodia Mucavele, R. Glyn Hewinson, M. Carmen Garcia-Pelayo, Benon B. Asiimwe, Leen Rigouts, Judith Bruchfeld, Françoise Portaels, Elena Hailu, Stephen V. Gordon, Anita Luise Michel, Alicia Aranaz, Sabrina Rodríguez, Naima Sahraoui, Paul D. van Helden, M. Beatrice Boniotti, Noel H. Smith, Bongo Naré Richard Ngandolo, James Dale, Annélle Müller, Berit Djønne, Maria Lodovica Pacciarini, Borna Müller, Laura Boschiroli |
| المصدر: | Europe PubMed Central Journal of Bacteriology, 193, 670-8 Journal of Bacteriology, 193, 3, pp. 670-8 |
| بيانات النشر: | American Society for Microbiology, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | DNA, Bacterial, Species complex, Genotype, Bacterial diseases, Molecular Sequence Data, Gene Dosage, Strains, Locus (genetics), Microbiology, Evolutionary genetics, parasitic diseases, Animals, Cluster Analysis, Insertion sequence, Molecular Biology, Sequence Deletion, Spoligotyping, Genetics, Mycobacterium bovis, Errata, biology, Molecular epidemiology, Nucleic acid sequence, Africa, East, Pathogenesis and modulation of inflammation Infection and autoimmunity [N4i 1], Sequence Analysis, DNA, Africa, Eastern, biology.organism_classification, DNA Fingerprinting, Bacterial Typing Techniques, DNA profiling, DNA Transposable Elements, Cattle, Geographical distribution, Tuberculosis, Bovine, Population Genetics and Evolution |
| الوصف: | We have identified a clonal complex of Mycobacterium bovis isolated at high frequency from cattle in Uganda, Burundi, Tanzania, and Ethiopia. We have named this related group of M. bovis strains the African 2 (Af2) clonal complex of M. bovis. Af2 strains are defined by a specific chromosomal deletion (RDAf2) and can be identified by the absence of spacers 3 to 7 in their spoligotype patterns. Deletion analysis of M. bovis isolates from Algeria, Mali, Chad, Nigeria, Cameroon, South Africa, and Mozambique did not identify any strains of the Af2 clonal complex, suggesting that this clonal complex of M. bovis is localized in East Africa. The specific spoligotype pattern of the Af2 clonal complex was rarely identified among isolates from outside Africa, and the few isolates that were found and tested were intact at the RDAf2 locus. We conclude that the Af2 clonal complex is localized to cattle in East Africa. We found that strains of the Af2 clonal complex of M. bovis have, in general, four or more copies of the insertion sequence IS 6110 , in contrast to the majority of M. bovis strains isolated from cattle, which are thought to carry only one or a few copies. |
| تدمد: | 1098-5530 0021-9193 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb39bd4744c6a695057138c1fb10069 https://doi.org/10.1128/jb.00750-10 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....dbb39bd4744c6a695057138c1fb10069 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10985530 00219193 |
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