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The experimental model of transition from compensated cardiac hypertrophy to failure created by transverse aortic constriction in mice

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العنوان: The experimental model of transition from compensated cardiac hypertrophy to failure created by transverse aortic constriction in mice
المؤلفون: Tsuneaki Homma, Takaaki Furihata, Shouji Matsushima, Yoshihiro Masaki, Masaya Tsuda, Takashi Yokota, Wataru Mizushima, Shintaro Kinugawa, Arata Fukushima, Hiroyuki Tsutsui, Shingo Takada, Masashige Takahashi, Junichi Matsumoto
المصدر: International Journal of Cardiology. Heart & Vasculature
Scipedia Open Access
Scipedia SL
International Journal of Cardiology: Heart & Vasculature, Vol 11, Iss C, Pp 24-28 (2016)
بيانات النشر: Elsevier BV, 2016.
سنة النشر: 2016
مصطلحات موضوعية: 0301 basic medicine, lcsh:Diseases of the circulatory (Cardiovascular) system, Cardiac failure, medicine.medical_specialty, Cardiac & Cardiovascular Systems, 030204 cardiovascular system & hematology, Article, Muscle hypertrophy, Mice, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Survival rate, business.industry, Experimental model, Aortic constriction, Methodology, Fractional shortening, Transverse aortic constriction, Cardiac hypertrophy, Transverse plane, 030104 developmental biology, lcsh:RC666-701, Cardiology, Cardiology and Cardiovascular Medicine, business, Wall thickness
الوصف: Background Transverse aortic constriction (TAC) operation is used as an experimental model of left ventricular (LV) hypertrophy and LV failure in mice. The severity of LV remodeling or failure may depend on the degree of TAC, but is variable among operated animals. Therefore, we tried to identify the optimal diameter of TAC to create this model with ease and high reproducibility. Methods and results To produce TAC in C57BL/6J mice (7–9 weeks, body weight 19–26 g, n = 109), a 7–0 nylon suture ligature was tightly tied around the transverse aorta against needles with 3 different diameters (mm); 0.40, 0.385 and 0.375. LV wall thickness, end-diastolic dimension, fractional shortening were measured by echocardiography. At 4 weeks after TAC, no mouse with the 0.400 mm gauge progressed in LV failure. The 0.385 mm pin gauge mouse kept a more survival rate compared with the 0.375 mm (59% vs 48%), representing same efficient in LV failure. With the 0.385 mm pin gauge, hearts of mice remained LV hypertrophy at 1 week after TAC, followed by LV failure at 4 weeks. Conclusion TAC with the diameter of 0.385 mm can effectively induce the transition from LV hypertrophy to failure in mice with relatively preserved survival.
وصف الملف: application/pdf
تدمد: 2352-9067
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb551b27f92c41ab8848fb866ad8db2
https://doi.org/10.1016/j.ijcha.2016.03.007
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....dbb551b27f92c41ab8848fb866ad8db2
قاعدة البيانات: OpenAIRE
الوصف
تدمد:23529067