Combined effects of bucillamine and etanercept on a rat type II collagen-induced arthritis model
| العنوان: | Combined effects of bucillamine and etanercept on a rat type II collagen-induced arthritis model |
|---|---|
| المؤلفون: | Osamu Katsuta, Chikako Setoguchi, Fumio Tsuji, Masahiro Okamoto, Hiroyuki Aono |
| المصدر: | Modern Rheumatology. 20:381-388 |
| بيانات النشر: | Oxford University Press (OUP), 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | medicine.medical_specialty, Combination therapy, medicine.medical_treatment, Arthritis, Pharmacology, Receptors, Tumor Necrosis Factor, Etanercept, Arthritis, Rheumatoid, Rheumatology, Internal medicine, Interleukin-1alpha, medicine, Animals, Cysteine, business.industry, Interleukin-6, Bucillamine, Anti-Inflammatory Agents, Non-Steroidal, Granulocyte-Macrophage Colony-Stimulating Factor, Drug Synergism, medicine.disease, Arthritis, Experimental, Rats, Disease Models, Animal, Cytokine, Immunoglobulin M, Rats, Inbred Lew, Rheumatoid arthritis, Antirheumatic Agents, Immunoglobulin G, Immunology, Polyarthritis, Drug Therapy, Combination, Female, business, medicine.drug |
| الوصف: | The combined effects of bucillamine (Buc) and etanercept (ETN) on a rat model of type II collagen (CII)-induced arthritis (CIA) after treatment onset were investigated. In the combination treatment, rats received Buc 30 mg/kg orally administered once daily from the onset of arthritis or from 4 days after the onset of arthritis and ETN 0.3 mg/kg subcutaneously administered once on the day of onset. The effects of monotherapy with Buc and ETN, respectively, and of Buc + ETN combination therapy on the resulting polyarthritis were evaluated by histopathological analyses and measurements of hindpaw volumes, serum anti-collagen antibody and immunoglobulin levels, and cytokine levels. The Buc + ETN therapeutic combination reduced hindpaw swelling, synovial proliferation, bone destruction, new bone formation, and inflammatory cell infiltration in CIA. Montherapy with Buc showed a tendency to ameliorate these symptoms, while monotherapy with ETN reduced hindpaw swelling at 4 days after administration but did not maintain treatment efficacy toward the end of the experimental period. Histopathological findings did not reveal any efficacy of the ETN therapy. ETN alone increased the serum immunoglobulin levels, while its combination with Buc reduced these levels. Similar results were obtained for serum anti-CII antibody titers. The Buc + ETN combination treatment also reduced serum interleuking (IL)-1alpha and granulocyte macrophage colony-stimulating factor and tended to reduce serum IL-1beta and IL-6 levels. These results suggest that a combination therapy of Buc and ETN may be effective for the treatment of rheumatoid arthritis (RA). |
| تدمد: | 1439-7609 1439-7595 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbd7a7d62103d1757d075974006554c1 https://doi.org/10.3109/s10165-010-0292-8 |
| رقم الأكسشن: | edsair.doi.dedup.....dbd7a7d62103d1757d075974006554c1 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. 
PDF full text from Publisher | تدمد: | 14397609 14397595 |
|---|