Predictors of clinical success after transcatheter para-valvular leak closure: an international prospective multicentre registry
| العنوان: | Predictors of clinical success after transcatheter para-valvular leak closure: an international prospective multicentre registry |
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| المؤلفون: | Hascoet, S, Smolka, G, Brochet, E, Bouisset, F, Leurent, G, Thambo, J, Combes, N, Bauer, F, Nejjari, M, Pilliere, R, Dauphin, C, Bonnet, G, Ketelers, R, Champagnac, D, Gerardin, B |
| المساهمون: | Hôpital Marie-Lannelongue, Medical University of Silesia (SUM), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Hôpital Haut-Lévêque [CHU Bordeaux], CHU Bordeaux [Bordeaux], CHU Rouen, Normandie Université (NU), Centre cardiologique du Nord (CCN), Hôpital de la Timone [CHU - APHM] (TIMONE), The study is promoted and financially supported by Groupe Hospitalier Paris Saint Joseph |
| المصدر: | European Heart Journal European Heart Journal, 2022, 43 (Supplement_2), pp.ehac544.2138. ⟨10.1093/eurheartj/ehac544.2138⟩ |
| بيانات النشر: | Oxford University Press (OUP), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Cardiology and Cardiovascular Medicine |
| الوصف: | Background Prosthetic paravalvular leaks (PVLs) are associated with congestive heart failure and haemolysis, for which the standard treatment is open-heart surgery with the attendant risks to the patient. Transcatheter closure has emerged as an alternative. Patient selection criteria for the best option are needed. We aimed to identify predictors of clinical success after transcatheter PVL closure. Purpose We aimed to identify predictors of clinical success after transcatheter PVL closure. Methods Consecutive patients referred to 24 European centres for transcatheter PVL closure in 2017–2019 were included in a prospective registry (Fermeture de Fuite ParaProthétique, FFPP). Clinical success was absence of any of the following within 1 month: re-admission for heart failure, blood transfusion, open-heart valvular surgery, and death. Results We included 216 symptomatic patients, who underwent 238 percutaneous PVL closure procedures on the mitral (64.3%), aortic (34.0%), or tricuspid (1.7%) valve. The prosthesis was mechanical in 53.3% and biological in 45.3% of procedures. All patients were symptomatic with heart failure, haemolytic anaemia, and the association of both conditions in 48.9%, 7.8% and 43.3%. One, two and three PVL were addressed during the same procedure in 69.6%, 26.6% and 3.8% respectively. Mitral and aortic PVL were severe in 35.3% and 13.8% (p Conclusion Transcatheter PVL closure is efficient and safe in symptomatic patients but is more challenging and associated with an increased risk of clinical failure when performed in patients with hemolysis and/or on a mechanical valve. Funding Acknowledgement Type of funding sources: Private hospital(s). Main funding source(s): The study is promoted and financially supported by Groupe Hospitalier Paris Saint Joseph |
| تدمد: | 1522-9645 0195-668X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc489c1e7a9a43e0d28dbc42601685b5 https://doi.org/10.1093/eurheartj/ehac544.2138 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....dc489c1e7a9a43e0d28dbc42601685b5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15229645 0195668X |
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