Utility of Urine Myoglobin for the Prediction of Acute Renal Failure in Patients with Suspected Rhabdomyolysis: A Systematic Review
| العنوان: | Utility of Urine Myoglobin for the Prediction of Acute Renal Failure in Patients with Suspected Rhabdomyolysis: A Systematic Review |
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| المؤلفون: | Karina Rodriguez-Capote, Adell El Sharif, Cynthia Balion, Lufang Yang, Richard Cleve, Stephen Hill |
| المصدر: | Clinical Chemistry. 55:2190-2197 |
| بيانات النشر: | Oxford University Press (OUP), 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | medicine.medical_specialty, Kidney, Myoglobin, business.industry, Biochemistry (medical), Clinical Biochemistry, MEDLINE, Evidence-based medicine, Urine, Acute Kidney Injury, Prognosis, medicine.disease, Rhabdomyolysis, Surgery, Study heterogeneity, medicine.anatomical_structure, Internal medicine, medicine, Etiology, Humans, business, Biomarkers, Kidney disease |
| الوصف: | Background: Urine myoglobin continues to be used as a marker of rhabdomyolysis, particularly to assess risk of developing acute renal failure and evaluate treatment success. We sought to determine the predictive validity of urine myoglobin (uMb) for acute renal failure (ARF) in patients with suspected rhabdomyolysis.Methods: We performed a broad systemic review of the literature from January 1980 to December 2006 using the search terms myoglobin$ AND (renal OR ARF OR kidney). Only primary studies published in English where uMb measurement was related to ARF were included.Results: Of 1602 studies screened, 52 met all selection criteria. The studies covered a wide spectrum of etiologies for rhabdomyolysis, dissimilar diagnostic criteria for ARF and rhabdomyolysis, and various methods of uMb measurement and were mostly case series (n = 32). There was poor reporting on the uMb method, and 17 studies failed to provide any information about the method. The reporting of clinical criteria for ARF with respect to timing, description, performance, and interpretation also lacked adequate detail for replication. Eight studies (total 295 patients) had data for 2-by-2 tables. Sensitivity of the uMb test was 100% in 5 of the 8 studies, specificity varied widely (15% to 88%), and CIs around these measures were high. Pooling of data was not possible because of study heterogeneity.Conclusions: There is inadequate evidence evaluating the use of uMb as a predictor of ARF in patients with suspected rhabdomyolysis. |
| تدمد: | 1530-8561 0009-9147 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc5afc11148bc487c5d82714407d2e03 https://doi.org/10.1373/clinchem.2009.128546 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....dc5afc11148bc487c5d82714407d2e03 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15308561 00099147 |
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