Combination treatment with sorafenib and wh‑4 additively suppresses the proliferation of liver cancer cells
| العنوان: | Combination treatment with sorafenib and wh‑4 additively suppresses the proliferation of liver cancer cells |
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| المؤلفون: | Su-Hong, Chen, Dan-Dan, Xu, Peng-Jun, Zhou, Yao, Wang, Qiu-Ying, Liu, Zhe, Ren, Zhong, Liu, Xia, Wang, Hui-Qing, Huang, Xue, Xue, Ying, Wang, Yi-Fei, Wang |
| المصدر: | Experimental and Therapeutic Medicine. 23 |
| بيانات النشر: | Spandidos Publications, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Cancer Research, Immunology and Microbiology (miscellaneous), General Medicine |
| الوصف: | Sorafenib is currently used to treat hepatocellular carcinoma (HCC). However, the development of chemoresistance to sorafenib is a major limitation for sorafenib-based therapy in patients with HCC. In the present study, the effect of the combination therapy of sorafenib and wh-4 on the proliferation of liver cancer cells was investigated. The results showed that sorafenib with wh-4 additively suppressed the proliferation of liver cancer cells. The colony formation of liver cancer cells decreased significantly in response to the combination treatment of sorafenib with wh-4, and it also induced the apoptosis of liver cancer cells. Western blot analysis demonstrated decreased expression of Bcl2, and increased expression of Bax in liver cancer cells treated with a combination of sorafenib and wh-4. Moreover, the migration of liver cancer cells was inhibited. The combination treatment of sorafenib with wh-4 reduced the expression levels of |
| تدمد: | 1792-1015 1792-0981 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc631c3778be39d1c798b9aa1071801e https://doi.org/10.3892/etm.2022.11156 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....dc631c3778be39d1c798b9aa1071801e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17921015 17920981 |
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