Identification, expression, and artificial selection of silkworm epigenetic modification enzymes
| العنوان: | Identification, expression, and artificial selection of silkworm epigenetic modification enzymes |
|---|---|
| المؤلفون: | Kunpeng Lu, Hai Hu, Min-Jin Han, Bili Zhang, Shubo Liang, Rui Gao, Yanyu Liu, Chunlin Li, Fangyin Dai, Yue Luan, Xiaoling Tong |
| المصدر: | BMC Genomics BMC Genomics, Vol 21, Iss 1, Pp 1-11 (2020) |
| بيانات النشر: | BioMed Central, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Epigenetic modifying enzymes, Male, Selective sweeping, lcsh:QH426-470, lcsh:Biotechnology, Biology, Genome, BmSuv4–20, Epigenesis, Genetic, Domestication, 03 medical and health sciences, Mice, 0302 clinical medicine, Bombyx mori, lcsh:TP248.13-248.65, Silkworm, Genetics, Animals, Domesticated traits, Epigenetics, Gene, Phylogeny, 030304 developmental biology, 0303 health sciences, Reproduction, fungi, biology.organism_classification, Bombyx, Phenotype, lcsh:Genetics, Drosophila melanogaster, Female, DNA microarray, BmDNMT2, 030217 neurology & neurosurgery, Biotechnology, Research Article |
| الوصف: | Background Understanding the genetic basis of phenotype variations during domestication and breeding is of great interest. Epigenetics and epigenetic modification enzymes (EMEs) may play a role in phenotypic variations; however, no comprehensive study has been performed to date. Domesticated silkworm (Bombyx mori) may be utilized as a model in determining how EMEs influence domestication traits. Results We identified 44 EMEs in the genome of silkworm (Bombyx mori) using homology searching. Phylogenetic analysis showed that genes in a subfamily among different animals were well clustered, and the expression pattern of EMEs is constant among Bombyx mori, Drosophila melanogaster, and Mus musculus. These are most highly expressed in brain, early embryo, and internal genitalia. By gene-related selective sweeping, we identified five BmEMEs under artificial selection during the domestication and breeding of silkworm. Among these selected genes, BmSuv4–20 and BmDNMT2 harbor selective mutations in their upstream regions that alter transcription factor-binding sites. Furthermore, these two genes are expressed higher in the testis and ovary of domesticated silkworm compared to wild silkworms, and correlations between their expression pattern and meiosis of the sperm and ova were observed. Conclusions The domestication of silkworm has induced artificial selection on epigenetic modification markers that may have led to phenotypic changes during domestication. We present a novel perspective to understand the genetic basis underlying animal domestication and breeding. |
| اللغة: | English |
| تدمد: | 1471-2164 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc9f8864cfc556f70c5ef8850199d92a http://europepmc.org/articles/PMC7585183 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....dc9f8864cfc556f70c5ef8850199d92a |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14712164 |
|---|