Time to Detection of Yeast Isolates in Pediatric and Adult Patients with Fungemia and its Relevance to Clinical Profile and Outcome
| العنوان: | Time to Detection of Yeast Isolates in Pediatric and Adult Patients with Fungemia and its Relevance to Clinical Profile and Outcome |
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| المؤلفون: | Vidya Gupta, Rajesh Chawla, Ali Ammar Jafri, Anupam Sibal, Hena Butta, Leena Mendiratta, Raman Sardana |
| المصدر: | Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine |
| بيانات النشر: | Jaypee Brothers Medical Publishing, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | medicine.diagnostic_test, Continuous monitoring automated blood culture systems, business.industry, Time to detection, Context (language use), Drug resistance, Critical Care and Intensive Care Medicine, medicine.disease, Yeast, Corpus albicans, Microbiology, Amphotericin B, Bacteremia, medicine, Original Article, Blood culture, business, Fungemia, medicine.drug |
| الوصف: | Context Time to detection (TTD) given by continuous monitoring automated blood culture systems (CMABS) have been found to be a predictor of clinical outcome, drug resistance and type of microorganism in cases of bacteremia but the studies evaluating TTD with respect to fungemia are scarce especially from India. Aims To evaluate TTD for yeast isolates in fungal bloodstream infections with respect to the type of yeast isolates, risk factors and outcome and to study yeast susceptibility and distribution of yeast isolates with respect to patient population. Materials and methods All blood culture specimens were processed in CMABS. The TTD for yeast isolates were recorded. The identification of yeast and susceptibility testing was done by automated methods. A correlation of TTD was done with respect to prior/concurrent yeast isolates, use of antifungal, risk factors and clinical outcome. Results Out of 80 yeast isolates, the maximum was C. parapsilosis (26.25%) followed by C. albicans (16.25%) and C. tropicalis (13.75%). A statistically significant difference in the occurrence of yeasts with early TTD (TTD < = 48 hours) and late TTD (TTD > 48 hours) was found. TTD of C. glabrata was significantly longer (p = 0.002) while TTD of C. tropicalis was significantly shorter (p = 0.013). There was an observable favorable outcome in shorter TTD (< = 48 hours). C. albicans and C. tropicalis depicted 100% susceptibility for Azoles, Amphotericin B and Echinocandins. Conclusion TTD may be used as both diagnostic and prognostic adjunct in fungal bloodstream infections. This study is a step towards this novel approach. We also emphasize on the importance of speciation of yeast isolates and susceptibility testing. How to cite this article Butta H, Sardana R, Mendiratta L, Sibal A, Gupta V, Chawla R, Jafri AA. Time to Detection of Yeast Isolates in Pediatric and Adult Patients with Fungemia and its Relevance to Clinical Profile and Outcome. Indian Journal of Critical Care Medicine, January 2019;23(1):27-30. |
| تدمد: | 1998-359X 0972-5229 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcb63547c61654717335c1a011e77708 https://doi.org/10.5005/jp-journals-10071-23108 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....dcb63547c61654717335c1a011e77708 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1998359X 09725229 |
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