Clearance of a productive lentivirus infection in calves experimentally inoculated with caprine arthritis-encephalitis virus
| العنوان: | Clearance of a productive lentivirus infection in calves experimentally inoculated with caprine arthritis-encephalitis virus |
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| المؤلفون: | Jitka Durand, Kathy Gallay, Délphine Grezel, Stephanie Villet, Théodore Alogninouwa, Thierry Morin, Baya Amel Bouzar, Céline Garnier, Francoise Gounel, Y. Chebloune, Jean-François Mornex, Laïla Mselli-Lakhal, Timothy Greenland, François Guiguen |
| المساهمون: | Rétrovirus et Pathologie Comparée (RPC), Institut National de la Recherche Agronomique (INRA)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Ecole Nationale Vétérinaire de Lyon (ENVL) |
| المصدر: | Journal of Virology Journal of Virology, American Society for Microbiology, 2003, 77 (11), pp.6430-6437. ⟨10.1128/JVI.77.11.6430-6437.2003⟩ |
| بيانات النشر: | HAL CCSD, 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | EXPRESSION, Arthritis-Encephalitis Virus, Caprine, 040301 veterinary sciences, medicine.medical_treatment, viruses, Immunology, Cattle Diseases, Antibodies, Viral, Virus Replication, Microbiology, Virus, 0403 veterinary science, 03 medical and health sciences, Retrovirus, Species Specificity, GOATS, Virology, medicine, Animals, Cytotoxic T cell, CELL-CULTURES, MACROPHAGES, Caprine arthritis encephalitis virus, Cells, Cultured, 030304 developmental biology, 0303 health sciences, MACAQUES, biology, Lentivirus Infections, Immunosuppression, 04 agricultural and veterinary sciences, biology.organism_classification, SIMIAN IMMUNODEFICIENCY VIRUS, 3. Good health, Animals, Newborn, Viral replication, SHEEP, Insect Science, DNA, Viral, Lentivirus, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Pathogenesis and Immunity, Cattle, VISNA VIRUSES, PRIMATE LENTIVIRUS, RESPONSES |
| الوصف: | Lentiviruses have long been considered host-specific pathogens, but several recent observations demonstrated their capacity to conquer new hosts from different species, genera, and families. From these cross-species infections emerged new animal and human infectious diseases. The successful colonization and adaptation of a lentivirus to a nonnatural host depends on unspecific and specific host barriers. Some of those barriers exert a relative control of viral replication (i.e., cytotoxic T-lymphocyte response, viral inhibitory factors), but none of them was found able to totally clear the infection once the retrovirus is fully adapted in its host. In this study we examined the evolution of the host-lentivirus interactions occurring in an experimental animal model of cross-species infection in order to analyze the efficiency of those barriers in preventing the establishment of a persistent infection. Five newborn calves were inoculated with caprine arthritis-encephalitis virus (CAEV), and the evolution of infection was studied for more than 12 months. All the animals seroconverted in the first 0.75 to 1 month following the inoculation and remained seropositive for the remaining time of the experiment. Viral infection was productive during 4 months with isolation of replication competent virus from the blood cells and organs of the early euthanized animals. After 4 months of infection, neither replication-competent virus nor virus genome could be detected in blood cells or in the classical target organs, even after an experimental immunosuppression. No evidence of in vitro restriction of CAEV replication was observed in cells from tissues explanted from organs of these calves. These data provide the demonstration of a natural clearance of lentivirus infection following experimental inoculation of a nonnatural host, enabling perspectives of development of new potential vaccine strategies to fight against lentivirus infections. |
| اللغة: | English |
| تدمد: | 0022-538X 1098-5514 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd03b784869a8736b0ff284c6c3292fc https://hal.inrae.fr/hal-02683135 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....dd03b784869a8736b0ff284c6c3292fc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0022538X 10985514 |
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