Effects of fat-to-sugar ratio in excess dietary energy on lipid abnormalities: a 7-month prospective feeding study in adult cynomolgus monkeys
| العنوان: | Effects of fat-to-sugar ratio in excess dietary energy on lipid abnormalities: a 7-month prospective feeding study in adult cynomolgus monkeys |
|---|---|
| المؤلفون: | Jun-Hua Rao, Zhi-Yuan Wei, Ke-Wei Wang, Jian-Huan Chen, Xiao Baiquan, Liu Yiyan, Bi-Hai Li |
| المصدر: | Lipids in Health and Disease, Vol 18, Iss 1, Pp 1-6 (2019) Lipids in Health and Disease |
| بيانات النشر: | BMC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Blood Glucose, Male, medicine.medical_specialty, Lipid abnormality, Clinical chemistry, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Administration, Oral, 030209 endocrinology & metabolism, Clinical nutrition, 030204 cardiovascular system & hematology, Fasting glucose, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Internal medicine, Dietary Carbohydrates, medicine, High fat, Animals, Prospective Studies, Sugar, lcsh:RC620-627, Triglycerides, Cynomolgus monkey, Triglyceride, Chemistry, Research, Cholesterol, HDL, Biochemistry (medical), High-sugar diet, Cholesterol, LDL, Dietary Fats, Macaca fascicularis, lcsh:Nutritional diseases. Deficiency diseases, High-fat diet, Female, High sugar, Sugars, Lipidology |
| الوصف: | Background Excess energy intake contributes to metabolic disorders. However, the relationship between excess sugar and fat in their contributions to metabolic abnormalities remains to be further elucidated. Here we conducted a prospective feeding experiment to evaluate effects of dietary fat-to-sugar ratio on diet-induced metabolic abnormalities in adult cynomolgus monkeys. Methods Four groups of adult cynomolgus monkeys were fed regular chow plus emulsion with combinations of high sugar (HS) or low sugar (HS) and low fat (LF) or high fat (HF) for 7 months. Plasma levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG) and blood glucose were measured for all the four groups of animals during the experiment. Results Plasma levels of TC and LDL-C gradually increased in all 4 diets groups, with the highest increase found in the LSHF group compared to the other three groups (P = 0.0018 and P = 0.0005 respectively). HF induced increased fasting glucose (P = 0.0077) and HS induced higher TG (P = 0.0227) respectively. Intriguingly, HSHF led to dramatically smaller magnitude of increase in LDL-C and TC levels compared to LSHF, while such difference was absent between the LSLF and LSHF groups. Our findings thus indicate interactive effects of HS and HF on TC and LDL-C. In addition, HF exhibited stronger effects on lipid abnormalities than HS. Conclusions In the current study, our prospective feeding experiment in adult cynomolgus monkeys revealed effects of different fat-to-sugar ratios on diet-induced metabolic abnormalities. Furthermore, our findings suggest that not only excess dietary energy but also the balance of dietary fat-to-sugar ratio matters in diet-induced lipid abnormalities. |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0c767ef45afcf464f4197a6ec9f822 http://link.springer.com/article/10.1186/s12944-018-0950-y |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....dd0c767ef45afcf464f4197a6ec9f822 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |