A Direct Comparison of Reactivity and Mechanism in the Gas Phase and in Solution
| العنوان: | A Direct Comparison of Reactivity and Mechanism in the Gas Phase and in Solution |
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| المؤلفون: | Kenneth Charles Westaway, Yao-ren Fang, Veronica M. Bierbaum, Nicole Eyet, Stephanie M. Villano, John M. Garver |
| المصدر: | Journal of the American Chemical Society. 132:3808-3814 |
| بيانات النشر: | American Chemical Society (ACS), 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | chemistry.chemical_classification, Iodide, Ethyl iodide, Solvation, General Chemistry, Photochemistry, Biochemistry, Catalysis, Solvent, chemistry.chemical_compound, Colloid and Surface Chemistry, Reaction rate constant, chemistry, Kinetic isotope effect, Solvent effects, Protic solvent |
| الوصف: | Direct comparisons of the reactivity and mechanistic pathways for anionic systems in the gas phase and in solution are presented. Rate constants and kinetic isotope effects for the reactions of methyl, ethyl, isopropyl, and tert-butyl iodide with cyanide ion in the gas phase, as well as for the reactions of methyl and ethyl iodide with cyanide ion in several solvents, are reported. In addition to measuring the perdeutero kinetic isotope effect (KIE) for each reaction, the secondary alpha- and beta-deuterium KIEs were determined for the ethyl iodide reaction. Comparisons of experimental results with computational transition states, KIEs, and branching fractions are explored to determine how solvent affects these reactions. The KIEs show that the transition state does not change significantly when the solvent is changed from dimethyl sulfoxide/methanol (a protic solvent) to dimethyl sulfoxide (a strongly polar aprotic solvent) to tetrahydrofuran (a slightly polar aprotic solvent) in the ethyl iodide-cyanide ion S(N)2 reaction in solution, as the "Solvation Rule for S(N)2 Reactions" predicts. However, the Solvation Rule fails the ultimate test of predicting gas phase results, where significantly smaller (more inverse) KIEs indicate the existence of a tighter transition state. This result is primarily attributed to the greater electrostatic forces between the partial negative charges on the iodide and cyanide ions and the partial positive charge on the alpha carbon in the gas phase transition state. Nevertheless, in evaluating the competition between S(N)2 and E2 processes, the mechanistic results for the solution and gas phase reactions are strikingly similar. The reaction of cyanide ion with ethyl iodide occurs exclusively by an S(N)2 mechanism in solution and primarily by an S(N)2 mechanism in the gas phase; only approximately 1% of the gas phase reaction is ascribed to an elimination process. |
| تدمد: | 1520-5126 0002-7863 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd16cb0a348ea306b65b2783cd026f51 https://doi.org/10.1021/ja909399u |
| رقم الأكسشن: | edsair.doi.dedup.....dd16cb0a348ea306b65b2783cd026f51 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15205126 00027863 |
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