The Tubular Damage Markers: Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 in Newborns with Intrauterine Growth Restriction
| العنوان: | The Tubular Damage Markers: Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 in Newborns with Intrauterine Growth Restriction |
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| المؤلفون: | Marek Szczepański, Barbara Bebko, Elżbieta Ewa Kulikowska, Monika Kamianowska, Anna Wasilewska |
| المصدر: | Neonatology. 115:169-174 |
| بيانات النشر: | S. Karger AG, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Urinary system, Intrauterine growth restriction, Lipocalin, Gastroenterology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Lipocalin-2, 030225 pediatrics, Internal medicine, medicine, Humans, Hepatitis A Virus Cellular Receptor 1, 030212 general & internal medicine, Subclinical infection, Pregnancy, Creatinine, Kidney, Fetal Growth Retardation, business.industry, Infant, Newborn, Acute Kidney Injury, medicine.disease, medicine.anatomical_structure, chemistry, Case-Control Studies, Pediatrics, Perinatology and Child Health, Kidney Failure, Chronic, Small for gestational age, Female, business, Biomarkers, Developmental Biology |
| الوصف: | Background: Intrauterine growth restriction (IUGR) is a poorly understood complication of pregnancy. It may be associated with various diseases in adulthood, such as hypertension, cardiovascular disease, insulin resistance, and end-stage renal disease. Objectives: The aim of this study was to check whether IUGR affects the function of renal tubules, as assessed by the tubular damage markers neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1). Methods: The study included 126 term neonates. Thirty-eight newborns were the result of pregnancies complicated by IUGR. Eighty-eight healthy newborns were the result of normal pregnancies with no prenatal or perinatal complications. The concentrations of urinary NGAL and KIM-1 were determined with a commercially available ELISA kit and were normalized for urinary creatinine (Cr) concentration. Results: We found a significantly higher urinary concentration of NGAL and NGAL/Cr ratio in newborns from pregnancies complicated by IUGR when compared to the reference group. We found that female gender was associated with a higher concentration of urinary NGAL and also urinary NGAL/Cr. Conclusions: This is the first work that demonstrates that urinary NGAL concentration and urinary NGAL/Cr are significantly higher in infants that are small for gestational age than in appropriate-for-gestational-age infants. This might indicate subclinical kidney damage in newborns with IUGR. |
| تدمد: | 1661-7819 1661-7800 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5acec4235cc5ee05fea3f4bacaa230 https://doi.org/10.1159/000494102 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....dd5acec4235cc5ee05fea3f4bacaa230 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16617819 16617800 |
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