Oral antioxidant treatment of men significantly improves the reproductive outcome of ivf cycles
| العنوان: | Oral antioxidant treatment of men significantly improves the reproductive outcome of ivf cycles |
|---|---|
| المؤلفون: | Elena Maccarini, Sara Stigliani, Paola Anserini, Emanuele Licata, Francesca Bovis, Rocco Rago, Paola Scaruffi, Claudia Massarotti, Fausta Sozzi, Alessandro Dal Lago, Ida Casciano |
| المصدر: | Journal of Clinical Medicine Volume 10 Issue 15 Journal of Clinical Medicine, Vol 10, Iss 3254, p 3254 (2021) |
| بيانات النشر: | MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Alpha-lipoic acid, Sperm quality, medicine.medical_treatment, 030232 urology & nephrology, Semen, ICSI, Article, Intracytoplasmic sperm injection, Andrology, 03 medical and health sciences, 0302 clinical medicine, Human fertilization, IVF outcomes, Medicine, reproductive and urinary physiology, Male fertility, Myo-inositol, Oral antioxidants, Azoospermia, Pregnancy, 030219 obstetrics & reproductive medicine, In vitro fertilisation, urogenital system, business.industry, General Medicine, medicine.disease, Sperm, business, Embryo quality |
| الوصف: | Some 30% to 80% of male sub-fertility may be associated with oxidative stress that damages spermatozoa and can decrease success of in vitro fertilization (IVF) techniques. This multicenter, longitudinal, prospective study aimed to investigate whether oral antioxidant supplementation improved the reproductive competence of men who had had low fertilization rates in their previous intracytoplasmic sperm injection (ICSI) cycles without azoospermia or severe oligozoospermia or any identifiable andrological disease. Seventy-seven men from couples who had an ICSI attempt with unexplained < 60% fertilization rate took an antioxidant mix of myo-inositol, alpha-lipoic acid, folic acid, coenzyme Q10, zinc, selenium, and vitamins B2, B6, and B12. Semen parameters were analyzed before (T0) and after 90 days (T90) of treatment, and outcomes of the paired T0 and T90 cycles were compared. After the treatment there was an increase in sperm concentration (p = 0.027), total motile sperm count (p = 0.003), progressive motility (p < 0.0001), and a decreasing trend of DNA-fragmented spermatozoa. Embryological outcomes (fertilization, embryo quality, blastocyst development) were significantly higher in T90 than T0 cycles. No T0 cycle resulted in an evolutive pregnancy. Conversely, in T90 cycles 29 singleton clinical pregnancies were obtained. No negative neonatal outcomes were recorded in newborns after antioxidant treatment. Diet supplementation of men who have had low fertilization rates in their previous ICSI cycles with a combination of myo-inositol, alpha-lipoic acid, folic acid, coenzyme Q10, zinc, selenium, betaine, and vitamins may improve semen reproductive potential and ICSI clinical outcome. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd620923253bb5d18cdd67a04fdf9243 http://hdl.handle.net/11567/1055278 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....dd620923253bb5d18cdd67a04fdf9243 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |