التفاصيل البيبلوغرافية
العنوان:
2-Alkyloxazoles as potent and selective PI4KIIIβ inhibitors demonstrating inhibition of HCV replication
المؤلفون:
Michael D. Connolly , Matthew J. LaMarche , Lawrence G. Hamann , Ayako Honda , Brigitte Wiedmann , Subramanian Karur , Shawn D. Britt , Markus Dobler , Rajeshri Ganesh Karki , Prakash Raman , Anup Patnaik , Samantha Sokup , Erin P. Keaney
المصدر:
Bioorganic & Medicinal Chemistry Letters . 24:3714-3718
بيانات النشر:
Elsevier BV, 2014.
سنة النشر:
2014
مصطلحات موضوعية:
Clinical Biochemistry , Pharmaceutical Science , Hepacivirus , Microbial Sensitivity Tests , Class iii , Virus Replication , Antiviral Agents , Biochemistry , Virus , Structure-Activity Relationship , Drug Discovery , Replication (statistics) , Genotype , Humans , Replicon , Beta (finance) , Oxazoles , Protein Kinase Inhibitors , Molecular Biology , Dose-Response Relationship, Drug , Molecular Structure , Chemistry , Organic Chemistry , Virology , Molecular biology , In vitro , Phosphotransferases (Alcohol Group Acceptor) , Molecular Medicine
الوصف:
Synthesis and SAR of 2-alkyloxazoles as class III phosphatidylinositol-4-kinase beta (PI4KIIIβ) inhibitors is described. These compounds demonstrate that inhibition of PI4KIIIβ leads to potent inhibition of HCV replication as observed in genotype (GT) 1a and 1b replicon and GT2a JFH1 virus assays in vitro.
تدمد:
0960-894X
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd89a1f44474311f1155702c2f42685c https://doi.org/10.1016/j.bmcl.2014.07.015
حقوق:
CLOSED
رقم الأكسشن:
edsair.doi.dedup.....dd89a1f44474311f1155702c2f42685c
قاعدة البيانات:
OpenAIRE
