Elevated Lipoprotein-Associated Phospholipase A2 Is Associated with Progression of Nonculprit Lesions after Percutaneous Coronary Intervention
| العنوان: | Elevated Lipoprotein-Associated Phospholipase A2 Is Associated with Progression of Nonculprit Lesions after Percutaneous Coronary Intervention |
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| المؤلفون: | Wei-Qiang Kang, Rui Zhang, Hui-Ping Gong, Shanglang Cai, Song Liu, Hui Xin, Quan-Fang Zhang, Zhexun Lian, Zuo-Yuan Chen, Xian-feng Ning, Zhi-Ming Ge |
| المصدر: | The Tohoku Journal of Experimental Medicine. 230:97-102 |
| بيانات النشر: | Tohoku University Medical Press, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, Acute coronary syndrome, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Coronary Angiography, General Biochemistry, Genetics and Molecular Biology, Body Mass Index, Pathogenesis, Percutaneous Coronary Intervention, Internal medicine, medicine, Humans, Acute Coronary Syndrome, Phospholipids, Aged, Anthropometry, business.industry, Hydrolysis, Lipoprotein-associated phospholipase A2, Percutaneous coronary intervention, General Medicine, Middle Aged, medicine.disease, Oxygen, Stenosis, Cholesterol, 1-Alkyl-2-acetylglycerophosphocholine Esterase, Multivariate Analysis, Conventional PCI, Disease Progression, Cardiology, Female, business, Body mass index, Biomarkers, Follow-Up Studies, Blood sampling |
| الوصف: | Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an enzyme that hydrolyzes oxidized phospholipids to generate bioactive proatherogenic products. Nonculprit lesions have been assumed to contribute to the pathogenesis of recurrent acute coronary syndrome (ACS). The role of LP-PLA2 in the progression of nonculprit coronary lesions after successful percutaneous coronary intervention (PCI) remains unclear. Our study included 123 patients with ACS who underwent initial PCI and a long-term follow-up (mean interval, one year) with coronary angiography. Among them, 19 patients were diagnosed as the progression of nonculprit lesions, based on the presence of at least one of the following factors: (1) ≥ 10% reduction in the diameter of a preexisting ≥ 50% stenosis; (2) ≥ 30% reduction in the diameter of a < 50% stenosis; and (3) early-onset stenosis with ≥ 30% reduction in the diameter of a segment that was normal on the primary angiogram. Blood sampling was drawn from all patients at 12-14 hours after PCI. The ACS patients with progression had higher total cholesterol (4.47 ± 1.02 mmol/L vs. 3.59 ± 0.57 mmol/L, P < 0.05), higher levels of Lp-PLA2 activity (14.39 ± 6.13 nmol/min/ml vs. 8.86 ± 3.14 nmol/min/ml, P < 0.001) and a higher proportion of multi-vessel disease than those without progression. Multivariate logistic regression analysis showed that Lp-PLA2 activity (β = 0.024, P = 0.005) was an independent predictor for rapid progression of nonculprit coronary lesions. In conclusion, elevated Lp-PLA2 activity is associated with rapid progression of nonculprit coronary lesions in ACS patients who underwent PCI. |
| تدمد: | 1349-3329 0040-8727 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd94538c7481a4ec81f8626e9d4c684e https://doi.org/10.1620/tjem.230.97 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....dd94538c7481a4ec81f8626e9d4c684e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13493329 00408727 |
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