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Dietary flavonoid and lignan intake and breast cancer risk according to menopause and hormone receptor status in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

التفاصيل البيبلوغرافية
العنوان: Dietary flavonoid and lignan intake and breast cancer risk according to menopause and hormone receptor status in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study
المؤلفون: Emily Sonestedt, Petra H.M. Peeters, Kaja Tikk, Anja Olsen, Lea Bredsdorff, Ruth C. Travis, Noémie Travier, Fulvio Ricceri, Raul Zamora-Ros, Annekatrin Lukanova, H. Bas Bueno-de-Mesquita, Krasimira Aleksandrova, Nicholas J. Wareham, Dagrun Engeset, Kim Overvad, Aurelio Barricarte, Elisabete Weiderpass, Guri Skeie, Peter Wallström, Giovanna Masala, María Dolores Chirlaque, Elio Riboli, Augustin Scalbert, Heather Ward, Pilar Amiano, Isabelle Romieu, Carlos A. González, Pietro Ferrari, Sabina Sieri, Kay Thee Khaw, Marina Touillaud, Vardis Dilis, Virginia Menéndez, Guy Fagherazzi, Amalia Mattiello, Antonia Trichopoulou, Heiner Boeing, Malin Sund, Esther Molina-Montes, Rikard Landberg, Florence Perquier, Rosario Tumino, Dimitrios Trichopoulos, Anne Tjønneland
المصدر: Zamora-Ros, R, Ferrari, P, González, C A, Tjønneland, A, Olsen, A, Bredsdorff, L, Overvad, K, Touillaud, M, Perquier, F, Fagherazzi, G, Lukanova, A, Tikk, K, Aleksandrova, K, Boeing, H, Trichopoulou, A, Trichopoulos, D, Dilis, V, Masala, G, Sieri, S, Mattiello, A, Tumino, R, Ricceri, F, Bueno-de-Mesquita, H B, Peeters, P H M, Weiderpass, E, Skeie, G, Engeset, D, Menéndez, V, Travier, N, Molina-Montes, E, Amiano, P, Chirlaque, M-D, Barricarte, A, Wallström, P, Sonestedt, E, Sund, M, Landberg, R, Khaw, K-T, Wareham, N J, Travis, R C, Scalbert, A, Ward, H A, Riboli, E & Romieu, I 2013, ' Dietary flavonoid and lignan intake and breast cancer risk according to menopause and hormone receptor status in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study ', Breast Cancer Research and Treatment, vol. 139, no. 1, pp. 163-76 . https://doi.org/10.1007/s10549-013-2483-4
Breast Cancer Research and Treatment; 139(1), pp 163-176 (2013)
سنة النشر: 2016
مصطلحات موضوعية: Adult, Cancer Research, medicine.medical_specialty, Physiology, Breast Neoplasms, Hormone receptors, Lignans, chemistry.chemical_compound, Breast cancer, Risk Factors, Surveys and Questionnaires, Humans, Medicine, Aged, Flavonoids, Gynecology, business.industry, Proportional hazards model, Incidence, Incidence (epidemiology), Hazard ratio, Middle Aged, Isoflavones, medicine.disease, Diet, European Prospective Investigation into Cancer and Nutrition, Postmenopause, Menopause, Premenopause, Receptors, Estrogen, Oncology, chemistry, Cancer and Oncology, Cohort, Female, Receptors, Progesterone, EPIC, business
الوصف: Evidence on the association between dietary flavonoids and lignans and breast cancer (BC) risk is inconclusive, with the possible exception of isoflavones in Asian countries. Therefore, we investigated prospectively dietary total and subclasses of flavonoid and lignan intake and BC risk according to menopause and hormonal receptor status in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The study included 334,850 women, mostly aged between 35 and 70 years from ten European countries. At baseline, country-specific validated dietary questionnaires were used. A flavonoid and lignan food composition database was developed from the US Department of Agriculture, the Phenol-Explorer and the UK Food Standards Agency databases. Cox regression models were used to analyse the association between dietary flavonoid/lignan intake and the risk of developing BC. During an average 11.5-year follow-up, 11,576 incident BC cases were identified. No association was observed between the intake of total flavonoids [hazard ratio comparing fifth to first quintile (HRQ5-Q1) 0.97, 95 % confidence interval (CI): 0.90-1.04; P trend = 0.591], isoflavones (HRQ5-Q1 1.00, 95 % CI: 0.91-1.10; P trend = 0.734), or total lignans (HRQ5-Q1 1.02, 95 % CI: 0.93-1.11; P trend = 0.469) and overall BC risk. The stratification of the results by menopausal status at recruitment or the differentiation of BC cases according to oestrogen and progesterone receptors did not affect the results. This study shows no associations between flavonoid and lignan intake and BC risk, overall or after taking into account menopausal status and BC hormone receptors.
وصف الملف: application/pdf
اللغة: English
تدمد: 1573-7217
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddea0c3fa3437dcc8cee09b30cb27017
https://ora.ox.ac.uk/objects/uuid:29745b93-2bcc-4a65-a446-a49c2fe42187
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....ddea0c3fa3437dcc8cee09b30cb27017
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15737217