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Microparticles Containing Curcumin Solid Dispersion: Stability, Bioavailability and Anti-Inflammatory Activity

التفاصيل البيبلوغرافية
العنوان: Microparticles Containing Curcumin Solid Dispersion: Stability, Bioavailability and Anti-Inflammatory Activity
المؤلفون: Luís Alexandre Pedro de Freitas, Leonardo Meneghin Mendonça, Mateus M. Bergamaschi, G. E. P. Souza, Lusânia Maria Greggi Antunes, Cristiane Cardoso Correia Teixeira, Regina Helena Costa Queiroz
المصدر: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
بيانات النشر: Springer Science and Business Media LLC, 2015.
سنة النشر: 2015
مصطلحات موضوعية: Male, Curcumin, Chemistry, Pharmaceutical, Anti-Inflammatory Agents, Biological Availability, Pharmaceutical Science, 02 engineering and technology, Aquatic Science, 030226 pharmacology & pharmacy, Fats, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Drug Stability, X-Ray Diffraction, Drug Discovery, Animals, Technology, Pharmaceutical, Rats, Wistar, Solubility, Dissolution, Ecology, Evolution, Behavior and Systematics, Aqueous solution, Chromatography, Ecology, Chemistry, General Medicine, Silicon Dioxide, 021001 nanoscience & nanotechnology, Rats, Bioavailability, Spray drying, Dispersion stability, ANÁLISE TÉRMICA, 0210 nano-technology, Dispersion (chemistry), Oils, Agronomy and Crop Science, Research Article
الوصف: This work aimed at improving the solubility of curcumin by the preparation of spray-dried ternary solid dispersions containing Gelucire®50/13-Aerosil® and quantifying the resulting in vivo oral bioavailability and anti-inflammatory activity. The solid dispersion containing 40% of curcumin was characterised by calorimetry, infrared spectroscopy and X-ray powder diffraction. The solubility and dissolution rate of curcumin in aqueous HCl or phosphate buffer improved up to 3600- and 7.3-fold, respectively. Accelerated stability test demonstrated that the solid dispersion was stable for 9 months. The pharmacokinetic study showed a 5.5-fold increase in curcumin in rat blood plasma when compared to unprocessed curcumin. The solid dispersion also provided enhanced anti-inflammatory activity in rat paw oedema. Finally, the solid dispersion proposed here is a promising way to enhance curcumin bioavailability at an industrial pharmaceutical perspective, since its preparation applies the spray drying, which is an easy to scale up technique. The findings herein stimulate further in vivo evaluations and clinical tests as a cancer and Alzheimer chemoprevention agent.
تدمد: 1530-9932
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddfcec72714109b85128f431941c25f7
https://doi.org/10.1208/s12249-015-0337-6
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....ddfcec72714109b85128f431941c25f7
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15309932