Asymptomatic Leishmania infection in blood donors from a major blood bank in Northeastern Brazil: a cross-sectional study
| العنوان: | Asymptomatic Leishmania infection in blood donors from a major blood bank in Northeastern Brazil: a cross-sectional study |
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| المؤلفون: | Manoel Sebastião da Costa Lima Junior, Lucas Portela Silva, Fábia Carla da Silva Soares, Suzany Maria Ferreira, Herintha Coeto Neitzke-Abreu, Filipe Dantas-Torres, Maria Betania do Amaral Pinto, Ana Cristina Bezerra, Silvia Maria Lucena Montenegro, Roberto Werkauser, Kamila Gaudêncio da Silva Sales, Vlaudia Maria Assis Costa |
| المصدر: | Revista do Instituto de Medicina Tropical de São Paulo, Vol 62 (2020) Revista do Instituto de Medicina Tropical de São Paulo; Vol. 62 (2020); e92 Revista do Instituto de Medicina Tropical de São Paulo; v. 62 (2020); e92 Revista do Instituto de Medicina Tropical de São Paulo Instituto de Medicina Tropical (IMT) instacron:IMT Revista do Instituto de Medicina Tropical de São Paulo, Volume: 62, Article number: e92, Published: 27 NOV 2020 |
| بيانات النشر: | Universidade de São Paulo, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Blood transfusion, Cross-sectional study, medicine.medical_treatment, 030231 tropical medicine, Population, RC955-962, Real-Time Polymerase Chain Reaction, Blood donors, Asymptomatic, 03 medical and health sciences, 0302 clinical medicine, Arctic medicine. Tropical medicine, parasitic diseases, medicine, Humans, Leishmania infantum, education, Asymptomatic Infections, Blood bank, Leishmania, education.field_of_study, Surveillance, biology, business.industry, Transmission (medicine), Asymptomatic infection, medicine.disease, biology.organism_classification, Visceral leishmaniasis, Cross-Sectional Studies, Population Surveillance, Immunology, Blood Banks, Leishmaniasis, Visceral, Female, Original Article, medicine.symptom, business, Brazil |
| الوصف: | This study has estimated the risk of Leishmania transmission via blood transfusion in one of the largest blood banks in Northeastern Brazil, where visceral leishmaniasis is endemic. Five hundred blood samples from donors were tested for circulating Leishmania spp. DNA by real-time PCR. Positive samples were tested by a species-specific conventional PCR targeting Leishmania infantum . Overall, 6.2% (95% CI: 4.1–8.3%) of the samples carried Leishmania DNA and in one sample the species was confirmed as L. infantum . No statistically significant differences were found in relation to gender, sex, education level, incomeas well as the place of residence between positive and negative blood donors. Our results confirm the presence of asymptomatic Leishmania carriers among blood donors in a large blood bank in Northeastern Brazil. Considering the studied population, we estimate that for every 1,000 blood donors screened, 41 to 83 will be positive for Leishmania DNA. This finding reinforces the urgent need for elaborating specific Blood bank guidelines to allow the early detection of asymptomatic Leishmania carriers among blood donors before their blood products are transfused to uninfected individuals. |
| وصف الملف: | application/pdf; text/html |
| اللغة: | English |
| تدمد: | 1678-9946 0036-4665 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de0370fdd7178971bbc29d8f9696e4dd http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652020000100244&tlng=en |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....de0370fdd7178971bbc29d8f9696e4dd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16789946 00364665 |
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