Prediction of cardiovascular outcome by estimated glomerular filtration rate among high-risk patients: a Thai nationwide cohort study
| العنوان: | Prediction of cardiovascular outcome by estimated glomerular filtration rate among high-risk patients: a Thai nationwide cohort study |
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| المؤلفون: | Noppawit Aiumtrakul, Annop Kittithaworn, Ouppatham Supasyndh, Rungroj Krittayaphong, Arintaya Phrommintikul, Bancha Satirapoj |
| المصدر: | Clinical and Experimental Nephrology. 26:1180-1193 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Male, Cohort Studies, Stroke, Cardiovascular Diseases, Risk Factors, Nephrology, Physiology, Physiology (medical), Humans, Female, Thailand, Cardiovascular System, Glomerular Filtration Rate |
| الوصف: | Decline of estimated glomerular filtration rate (eGFR) is associated with increased cardiovascular (CV) morbidity and mortality, but the predictive value of different eGFR on CV outcomes is limited in Southeast Asian populations.We aimed to stratify CV outcomes according to renal function among Thai patients with high atherosclerosis risk.We performed a secondary analysis in a 5-year national cohort entitled "CORE-Thailand study." Subjects were classified in 6 groups according to baseline kidney function: group I, eGFR ≥ 90; group II, eGFR 60-89; group IIIa, eGFR 45-59; group IIIb, eGFR 30-44; group IV, eGFR 15-29; group V, eGFR 15 ml/min/1.73 mA total of 6376 subjects (3467 men and 2909 women) were categorized in 6 groups. After adjusting covariates in the Cox proportional hazards model, compared to group I, subjects in groups II-V had a 1.65-fold, 2.17-fold, 2.67-fold, 4.24-fold, and 4.87-fold risk for 4-point MACE, respectively, with statistical significance at P 0.05 in all groups. Kaplan-Meier analysis illustrated stepwise lower survivals from 4-point MACE following the groups with lower baseline eGFR (log-rank test with P 0.001). All secondary outcomes showed similar trends as the primary outcome, except nonfatal stroke.Lower baseline kidney function was independently associated with increased risk of CV events and all-cause mortality in Thai populations at high CV risk. |
| تدمد: | 1437-7799 1342-1751 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de39e86f179d7d67a38912b08649a752 https://doi.org/10.1007/s10157-022-02262-5 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....de39e86f179d7d67a38912b08649a752 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14377799 13421751 |
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