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Expression of human ecto 5' nucleotidase in pig endothelial cells and its implication for adenosine production and xenotransplantation

التفاصيل البيبلوغرافية
العنوان: Expression of human ecto 5' nucleotidase in pig endothelial cells and its implication for adenosine production and xenotransplantation
المؤلفون: Charlotte Lawson, Magdi H. Yacoub, R. T. Smolenski, Marialuisa Lavitrano, Marlene L. Rose, Foy N Osborne, Kameljit K. Kalsi
المصدر: Nucleosides, nucleotidesnucleic acids. 24(4)
سنة النشر: 2005
مصطلحات موضوعية: Adenosine, DNA, Complementary, Time Factors, Swine, Xenotransplantation, medicine.medical_treatment, Transgene, Transplantation, Heterologous, Biochemistry, 5'-nucleotidase, Cell Line, Animals, Genetically Modified, Adenosine Triphosphate, Genetics, medicine, Extracellular, Animals, Humans, Nucleotide, 5'-Nucleotidase, Cells, Cultured, chemistry.chemical_classification, Inflammation, Graft Survival, General Medicine, Molecular biology, Enzyme, chemistry, Molecular Medicine, Graft survival, Endothelium, Vascular, medicine.drug
الوصف: Human endothelial activity of ecto-5′-nucleotidase (E5′N) is several times higher than in pig endothelial cells. This may have implication for xenotransplantation due to the role this enzyme plays in conversion of pro-inflammatory and pro-aggreggatory nucleotides into anti-inflammatory and anti-aggregatory adenosine. We have shown in this study that human E5′N can be functionally expressed in pig endothelial cells leading to increased adenosine production from both extracellular AMP and ATP. We suggest that E5′N expression in transgenic pigs for xenotransplantation may help to prolong graft survival.
تدمد: 1525-7770
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::decb0b4b536f0847365a129318108c31
https://pubmed.ncbi.nlm.nih.gov/16021917
رقم الأكسشن: edsair.doi.dedup.....decb0b4b536f0847365a129318108c31
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15257770