Ayurveda botanicals in COVID-19 management: An in silico multi-target approach
| العنوان: | Ayurveda botanicals in COVID-19 management: An in silico multi-target approach |
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| المؤلفون: | Aniket Marathe, Vedika Bhat, Akash Saggam, Sneha Sagar, Manali Joshi, Girish Tillu, Swapnil P. Borse, Preeti Chavan-Gautam, Lal Hingorani, Safal Walia, Aboli Girme |
| المصدر: | PLoS ONE, Vol 16, Iss 6, p e0248479 (2021) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | RNA viruses, Viral Diseases, Phytochemistry, Coronaviruses, Physiology, medicine.medical_treatment, Phytochemicals, Plant Science, Tinospora cordifolia, Biochemistry, Medical Conditions, Docking (dog), Immune Physiology, Medicine and Health Sciences, Drug Interactions, Immune Response, Pathology and laboratory medicine, Coronavirus 3C Proteases, Innate Immune System, Coronavirus RNA-Dependent RNA Polymerase, Multidisciplinary, biology, Traditional medicine, Plant Biochemistry, Antimicrobials, Withania, Drugs, Proteases, Medical microbiology, Antivirals, Enzymes, Molecular Docking Simulation, Chemistry, Infectious Diseases, Viruses, Physical Sciences, Spike Glycoprotein, Coronavirus, Cytokines, Medicine, SARS CoV 2, Pathogens, Asparagus Plant, Adjuvant, Research Article, Protein Binding, Tinospora, SARS coronavirus, Science, Immunology, Herb-Drug Interactions, India, Withania somnifera, Microbiology, Antiviral Agents, Signs and Symptoms, Pharmacotherapy, Viral life cycle, Microbial Control, Virology, medicine, Humans, Immunologic Factors, Asparagus racemosus, Pharmacology, Inflammation, Binding Sites, Biology and life sciences, Plant Extracts, SARS-CoV-2, Organisms, Viral pathogens, Proteins, COVID-19, Covid 19, Molecular Development, biology.organism_classification, Microbial pathogens, Medicine, Ayurvedic, COVID-19 Drug Treatment, Immune System, Enzymology, Clinical Medicine, Developmental Biology, Phytotherapy |
| الوصف: | The Coronavirus disease (COVID-19) caused by the virus SARS-CoV-2 has become a global pandemic in a very short time span. Currently, there is no specific treatment or vaccine to counter this highly contagious disease. There is an urgent need to find a specific cure for the disease and global efforts are directed at developing SARS-CoV-2 specific antivirals and immunomodulators. AyurvedicRasayanatherapy has been traditionally used in India for its immunomodulatory and adaptogenic effects, and more recently has been included as therapeutic adjuvant for several maladies. Amongst several others,Withania somnifera(Ashwagandha),Tinospora cordifolia(Guduchi) andAsparagus racemosus(Shatavari) play an important role inRasayanatherapy. The objective of this study was to explore the immunomodulatory and anti SARS-CoV2 potential of phytoconstituents from Ashwagandha, Guduchi and Shatavari using network pharmacology and docking. The plant extracts were prepared as per ayurvedic procedures and a total of 31 phytoconstituents were identified using UHPLC-PDA and mass spectrometry studies. To assess the immunomodulatory potential of these phytoconstituents anin-siliconetwork pharmacology model was constructed. The model predicts that the phytoconstituents possess the potential to modulate several targets in immune pathways potentially providing a protective role. To explore if these phytoconstituents also possess antiviral activity, docking was performed with the Spike protein, Main Protease and RNA dependent RNA polymerase of the virus. Interestingly, several phytoconstituents are predicted to possess good affinity for the three targets, suggesting their application for the termination of viral life cycle. Further, predictive tools indicate that there would not be adverse herb-drug pharmacokinetic-pharmacodynamic interactions with concomitantly administered drug therapy. We thus make a compelling case to evaluate the potential of theseRasayanabotanicals as therapeutic adjuvants in the management of COVID-19 following rigorous experimental validation. |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dee6716e2e21ee93bde7b4714b376059 https://doi.org/10.1371/journal.pone.0248479 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....dee6716e2e21ee93bde7b4714b376059 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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