A phase II study of biweekly pemetrexed and gemcitabine in patients with metastatic breast cancer
| العنوان: | A phase II study of biweekly pemetrexed and gemcitabine in patients with metastatic breast cancer |
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| المؤلفون: | Rakesh Goel, Roanne J. Segal, Oliver Keller, Shailendra Verma, Susan Dent, Vince Young, Stan Gertler, Christina Canil, Neill Iscoe |
| المصدر: | Cancer Chemotherapy and Pharmacology. 65:557-561 |
| بيانات النشر: | Springer Science and Business Media LLC, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Oncology, Cancer Research, medicine.medical_specialty, Guanine, medicine.drug_class, Breast Neoplasms, Pemetrexed, Toxicology, Deoxycytidine, Antimetabolite, Drug Administration Schedule, Glutamates, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Humans, Medicine, Pharmacology (medical), Neoplasm Metastasis, Fatigue, Aged, Pharmacology, Performance status, business.industry, Pneumonia, Exanthema, Middle Aged, medicine.disease, Gemcitabine, Chemotherapy regimen, Metastatic breast cancer, Anorexia, Surgery, Regimen, Treatment Outcome, Female, business, Febrile neutropenia, medicine.drug |
| الوصف: | Pemetrexed (PEM) is a novel folate antimetabolite which inhibits thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyl transferase. This phase II study was designed to assess the efficacy of Gemcitabine (GEM) and PEM given in a novel schedule in metastatic breast cancer (MBC) patients. Eligible patients had MBC and received one prior chemotherapy regimen for metastatic disease; Performance status (PS) 0–2; measurable disease (RECIST criteria). PEM(500 mg/m2) was administered intravenously (IV) over 10 min prior to GEM(1,500 mg/m2) IV given over 30 min on day 1 every 14 days. Median age of the 16 patients in the study was 54 years (range 33–77). Fourteen patients had a PS of 0/1 and were evaluable for response. There were no reported complete or partial responses, seven patients with stable disease, six patients with disease progression and one patient with unknown response. Most common toxicities were skin rash: Grade 1/2(8) and Grade 3/4(1). Grade 3/4 non-hematological toxicities were fatigue(1); anorexia(1); pneumonia(1); peripheral ischemia(1) and elevation of liver transaminases(1). Three patients experienced febrile neutropenia (FN). This study did not meet the predefined criteria to proceed with additional accrual. This regimen of PEM and GEM showed no clinical activity in the dose and schedule tested. |
| تدمد: | 1432-0843 0344-5704 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df064b86fa4ef41ab44a5e9a6bb3185c https://doi.org/10.1007/s00280-009-1064-z |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....df064b86fa4ef41ab44a5e9a6bb3185c |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14320843 03445704 |
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