Transformation of Small B-Cell Lymphoma Into Large Cell CD30+, CD4+, Epstein-Barr Virus–Negative Lymphoma
| العنوان: | Transformation of Small B-Cell Lymphoma Into Large Cell CD30+, CD4+, Epstein-Barr Virus–Negative Lymphoma |
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| المؤلفون: | Roland Schwarting, Ly Ma, Kristina J. Fasig, Cindy L. Vnencak-Jones, Aaron C. Shaver, Annette S. Kim |
| المصدر: | Archives of Pathology & Laboratory Medicine. 138:1101-1105 |
| بيانات النشر: | Archives of Pathology and Laboratory Medicine, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, Pathology, medicine.medical_specialty, CD30, Biopsy, Gene Rearrangement, B-Lymphocyte, Heavy Chain, Ki-1 Antigen, Biology, medicine.disease_cause, Pathology and Forensic Medicine, Diagnosis, Differential, immune system diseases, hemic and lymphatic diseases, medicine, Humans, Gene Rearrangement, B-Lymphocyte, B-cell lymphoma, Lymphoma, Follicular, Histiocyte, Large cell, General Medicine, Gene rearrangement, Middle Aged, medicine.disease, Leukemia, Lymphocytic, Chronic, B-Cell, Epstein–Barr virus, Neoplasm Proteins, Lymphoma, Medical Laboratory Technology, Cell Transformation, Neoplastic, Proto-Oncogene Proteins c-bcl-2, CD4 Antigens, Lymphoma, Large-Cell, Anaplastic, Immunoglobulin heavy chain, Female, Lymphoma, Large B-Cell, Diffuse, Neoplasm Grading, Biomarkers |
| الوصف: | We report here 2 separate cases in which patients with known low-grade B-cell lymphomas presented with transformed lesions that were CD30+, CD4+, Epstein-Barr virus negative, and negative or focally weak for a wide range of B-cell, T-cell, and histiocytic/dendritic cell markers. In each case the transformed lymphoma possessed an identical pattern of immunoglobulin heavy chain and/or BCL2 rearrangement to the corresponding original low-grade B-cell lymphoma, confirming their identity as transformed B-cell lymphoma. A review of the relevant literature reveals that, to our knowledge, no transformed B-cell lymphomas with this immunophenotype have been previously reported, which creates the opportunity for potential errors of diagnosis. These cases highlight the importance of correlation with the patient's history and with molecular genetic results in rendering an accurate diagnosis. |
| تدمد: | 1543-2165 0003-9985 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df074a064225e27a632a79957a23aebe https://doi.org/10.5858/arpa.2013-0089-cr |
| رقم الأكسشن: | edsair.doi.dedup.....df074a064225e27a632a79957a23aebe |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15432165 00039985 |
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