Intra-Individual Changes of Active Matrix Metalloproteinase-9 Are Associated with Clinical In-Stent Restenosis of Bare Metal Stents
| العنوان: | Intra-Individual Changes of Active Matrix Metalloproteinase-9 Are Associated with Clinical In-Stent Restenosis of Bare Metal Stents |
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| المؤلفون: | Gregory T. Jones, V.H.T. Chen, L.V. Phillips, Michael J.A. Williams, Gerard T. Wilkins, A.M. van Rij, Gregory P. Tarr |
| المصدر: | Cardiology. 124:28-35 |
| بيانات النشر: | S. Karger AG, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, Bare-metal stent, medicine.medical_specialty, medicine.medical_treatment, Myocardial Infarction, Coronary Restenosis, Percutaneous Coronary Intervention, Text mining, Risk Factors, Internal medicine, medicine, Humans, Bare metal, Pharmacology (medical), Myocardial infarction, Metalloproteinase, business.industry, Percutaneous coronary intervention, Middle Aged, medicine.disease, Intra individual, humanities, body regions, Matrix Metalloproteinase 9, Cardiology, Female, Stents, In stent restenosis, Cardiology and Cardiovascular Medicine, business |
| الوصف: | Objectives: Increased chronic postprocedural levels of active matrix metalloproteinase-9 (MMP-9) have been associated retrospectively with a history of in-stent restenosis (ISR). This study aimed to determine whether index or post-percutaneous coronary intervention (PCI) plasma levels of active MMP-9 are a predictor of subsequent clinical ISR, in a standard population of patients treated with bare metal coronary stents. Methods: Four hundred thirty-two patients were prospectively recruited and sampled at index and 3 and 6 months after PCI. Those who developed symptomatic angiographically confirmed ISR were compared to randomly selected, asymptomatic controls, stratified by index presentation in a nested case-control design. Plasma samples were analyzed for the active form of MMP-9. Results: In all, 35 patients (8.1%) developed ISR, and these were compared to 98 controls. The increase in active MMP-9 over 3 months was significantly greater in the ISR group (p = 0.030) and independent of the established risk factors. Index clinical presentation was not associated with acute changes in active MMP-9; however, patients with ST-elevation myocardial infarction had greater increases in active MMP-9 at 3 months. Conclusions: The change in active MMP-9 over 3 months after bare metal coronary stent placement appears to be independently associated with the development of ISR in a standard PCI population. |
| تدمد: | 1421-9751 0008-6312 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df4ce6a5c7e402372380928bd82096de https://doi.org/10.1159/000345591 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....df4ce6a5c7e402372380928bd82096de |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14219751 00086312 |
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