Effects of low- and high-intensity physical exercise on physical and cognitive function in older persons with dementia
| العنوان: | Effects of low- and high-intensity physical exercise on physical and cognitive function in older persons with dementia |
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| المؤلفون: | Esther G.A. Karssemeijer, L. M. J. Sanders, Erik J. A. Scherder, Tibor Hortobágyi, E A van der Zee, M. J. G. van Heuvelen |
| المساهمون: | AMS - Rehabilitation & Development, AMS - Ageing & Vitality, IBBA, Clinical Neuropsychology, SMART Movements (SMART), Van der Zee lab |
| المصدر: | Alzheimer's Research and Therapy, 12(1):28, 1-15. BioMed Central Alzheimer's Research & Therapy, 12 Alzheimers research & therapy, 12(1):28. BioMed Central Ltd. Sanders, L M J, Hortobágyi, T, Karssemeijer, E G A, Van Der Zee, E A, Scherder, E J A & Van Heuvelen, M J G 2020, ' Effects of low-and high-intensity physical exercise on physical and cognitive function in older persons with dementia : a randomized controlled trial ', Alzheimer's Research and Therapy, vol. 12, no. 1, 28, pp. 1-15 . https://doi.org/10.1186/s13195-020-00597-3 Alzheimer's Research & Therapy Alzheimer's Research & Therapy, 12, 1 Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-15 (2020) |
| بيانات النشر: | BioMed Central Ltd., 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Alzheimer`s disease Donders Center for Medical Neuroscience [Radboudumc 1], Dose-response relationship, Cognitive decline, lcsh:RC346-429, law.invention, Cognition, 0302 clinical medicine, Randomized controlled trial, law, Medicine, 030212 general & internal medicine, Netherlands, Aged, 80 and over, Psychomotor learning, RESISTANCE-EXERCISE, WALKING PROGRAM, APOE GENOTYPE, Exercise Therapy, ALZHEIMERS-DISEASE, Neurology, Female, AEROBIC EXERCISE, Exercise intensity, medicine.medical_specialty, Strength training, Cognitive Neuroscience, Physical exercise, lcsh:RC321-571, ApoE4, ADL PERFORMANCE, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, GROWTH-FACTOR-I, Humans, Aerobic exercise, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Exercise, lcsh:Neurology. Diseases of the nervous system, Aged, business.industry, Research, Training effect, TRAINING-PROGRAM, PERFORMANCE-MEASURES, Physical therapy, Dementia, Neurology (clinical), business, 030217 neurology & neurosurgery, NEUROTROPHIC FACTOR |
| الوصف: | Background Potential moderators such as exercise intensity or apolipoprotein-E4 (ApoE4) carriership may determine the magnitude of exercise effects on physical and cognitive functions in patients with dementia (PwD). We determined the effects of a 24-week aerobic and strength training program with a low- and high-intensity phase on physical and cognitive function. Methods In an assessor-blinded randomized trial, 91 PwD (all-cause dementia, recruited from daycare and residential care facilities, age 82.3 ± 7.0 years, 59 women, Mini-Mental State Examination 20.2 ± 4.4) were allocated to the exercise or control group. In the exercise group, PwD participated in a walking and lower limb strength training program with 12 weeks low- and 12 weeks high-intensity training offered three times/week. Attention-matched control participants performed flexibility exercises and recreational activities. We assessed adherence, compliance, and exercise intensity for each session. We assessed physical (endurance, gait speed, mobility, balance, leg strength) and cognitive (verbal memory, visual memory, executive function, inhibitory control, psychomotor speed) functions with performance-based tests at baseline and after 6, 12, 18, 24, and 36 weeks (follow-up). ApoE4 carriership was determined post-intervention. Results Sixty-nine PwD were analyzed. Their mean attendance was ~ 60% during the study period. There were no significant effects of the exercise vs. control intervention on endurance, mobility, balance, and leg strength in favor of the exercise group (Cohen’s d = 0.13–0.18). Gait speed significantly improved with ~ 0.05 m/s after the high-intensity phase for exercise participants (Cohen’s d = 0.41) but declined at follow-up. There were no significant effects of the exercise vs. control intervention on any of the cognitive measures (Cohen’s d ~ − 0.04). ApoE4 carriership did not significantly moderate exercise effects on physical or cognitive function. Conclusions Exercise was superior to control activities for gait speed in our sample of PwD. However, the training effect provided no protection for mobility loss after detraining (follow-up). There were no beneficial effects of the exercise vs. control group on cognitive function. Exercise intensity moderated the effects of exercise on gait speed. ApoE4 carriership moderated the effect of exercise on global cognition only (trend level). Trial registration Netherlands Trial Register, NTR5035. Registered on 2 March 2015. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1758-9193 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df65df8a3d510dc3112857be5937937c https://research.rug.nl/en/publications/bb193d98-9c92-4ed2-94c4-0c9f156022ae |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....df65df8a3d510dc3112857be5937937c |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 17589193 |
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