Micronutrient concentrations in respiratory syncytial virus and human metapneumovirus in Yemeni children
| العنوان: | Micronutrient concentrations in respiratory syncytial virus and human metapneumovirus in Yemeni children |
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| المؤلفون: | Bernard J. Brabin, N. Al-Aghbari, Najla Al-Sonboli, C. A. Hart, Z Atef, E. Roberts, Greg Harper, A. Al-Aryani, Alan Shenkin, Luis E. Cuevas |
| المساهمون: | Paediatric Infectious Diseases / Rheumatology / Immunology |
| المصدر: | Annals of tropical paediatrics, 29(1), 35-40. Maney Publishing |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Male, Yemen, Paramyxoviridae, viruses, Respiratory Syncytial Virus Infections, Virus, Pneumovirinae, Selenium, Human metapneumovirus, Medicine, Humans, Vitamin E, Metapneumovirus, Micronutrients, Prospective Studies, Mononegavirales, Vitamin A, Paramyxoviridae Infections, biology, business.industry, Infant, Newborn, virus diseases, Infant, Pneumovirus, respiratory system, Micronutrient, biology.organism_classification, Virology, respiratory tract diseases, Zinc, C-Reactive Protein, Pediatrics, Perinatology and Child Health, Female, business, Copper |
| الوصف: | BACKGROUND: Acute respiratory infections (ARI) cause significant childhood mortality. Nutritional homeostasis, particularly micronutrient levels, is important in modulating response to infection. More information is required regarding micronutrient levels in ARI viral infections, especially newly identified viruses such as human metapneumovirus (HMPV). AIM: To describe zinc, copper, selenium and vitamins A and E concentrations in children with respiratory syncytial virus (RSV) and/or HMPV in relation to levels of C-reactive protein (CRP). METHODS: The presence of RSV/HMPV in nasopharyngeal aspirates (NPA) was identified in 246 children using RTPCR. Zinc, copper, selenium and vitamins A and E concentrations were measured using inductive coupled plasma mass spectrometry and high performance liquid chromatography. RESULTS: 183 children had RSV, 39 had HMPV and 24 were co-infected. Zinc concentrations were lower in children with HMPV than in children with RSV or RSV/HMPV co-infection. Copper concentrations were lower in children with RSV than in children with RSV/HMPV or HMPV and zinc/copper ratios were lower in children with HMPV/RSV or RSV than in children with HMPV alone. Retinol and a alpha-tocopherol were lower in children with RSV than in children with HMPV. Most children had low selenium concentrations. Children with RSV and raised CRP (>5 mg/L) had higher copper and lower zinc/copper ratios than those with low CRP ( |
| تدمد: | 1465-3281 0272-4936 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df774c663a23f443bf391b9886c32860 https://pubmed.ncbi.nlm.nih.gov/19222932 |
| حقوق: | RESTRICTED |
| رقم الأكسشن: | edsair.doi.dedup.....df774c663a23f443bf391b9886c32860 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 14653281 02724936 |
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