Poly(I:C)-Mediated Death of Human Prostate Cancer Cell Lines Is Induced by Interleukin-27 Treatment
| العنوان: | Poly(I:C)-Mediated Death of Human Prostate Cancer Cell Lines Is Induced by Interleukin-27 Treatment |
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| المؤلفون: | Olena Kourko, Sam Basta, Daniela Cino, Robin Smyth, Katrina Gee, So Young Eo, Kyle Seaver, Carlene Petes |
| المصدر: | Journal of Interferon & Cytokine Research. 39:483-494 |
| بيانات النشر: | Mary Ann Liebert Inc, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Interleukin-27, Programmed cell death, medicine.medical_treatment, Immunology, Antineoplastic Agents, urologic and male genital diseases, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, DU145, Virology, Tumor Cells, Cultured, medicine, Humans, Interleukin 27, Cell Proliferation, Cell Death, Dose-Response Relationship, Drug, Chemistry, Prostatic Neoplasms, Interleukin, Cell Biology, Poly I-C, 030104 developmental biology, Cytokine, Apoptosis, Cell culture, 030220 oncology & carcinogenesis, PC-3 Cells, Cancer cell, Cancer research, Drug Screening Assays, Antitumor |
| الوصف: | Interleukin (IL)-27 is a promising anti-cancer cytokine with therapeutic potential. Exhibiting overlapping properties with type I and II interferons (IFNs), IL-27 impacts cancer cell viability and immune cell activity. Known to modulate toll-like receptor (TLR) expression, we investigated whether IL-27 affected TLR-mediated death in cancer cells. Using DU145 and PC3 cell lines as models of prostate cancer, we investigated whether IL-27 and IFN-γ affect TLR3-mediated cell death. Our results demonstrate that when IL-27 or IFN-γ is added with polyinosinic-polycytidylic acid [poly(I:C)], type I IFN (IFN-I) expression increases concurrently with cell death. IL-27 and IFN-γ enhanced TLR3 expression, suggesting a mechanism for sensitization to cell death. Further, PC3 cells were more sensitive to IL-27/poly(I:C)-induced cell death compared with DU145 cells. This correlated with higher production of IFN-β and inducible protein-10 versus IL-6 in response to treatment of PC3 cells compared with DU145. Taken together, this study demonstrates a potential role for IL-27 in the treatment of prostate cancer. |
| تدمد: | 1557-7465 1079-9907 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df93e18bc67f88bc37340e6b6a08c985 https://doi.org/10.1089/jir.2018.0166 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....df93e18bc67f88bc37340e6b6a08c985 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15577465 10799907 |
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