التفاصيل البيبلوغرافية
| العنوان: |
Long Noncoding RNA LINC01234 Functions as a Competing Endogenous RNA to Regulate CBFB Expression by Sponging miR-204-5p in Gastric Cancer |
| المؤلفون: |
Sheng-nan Ren, Hangjiang Fu, Shanxun Yu, Qinnan Chen, Tianwei Xu, Shuai Yan, Zhaoxia Wang, Chenchen Wei, Fengqi Nie, Zhenyao Chen, Xin Chen, Ming Sun, Pei Ma |
| المصدر: |
Clinical cancer research : an official journal of the American Association for Cancer Research. 24(8) |
| سنة النشر: |
2017 |
| مصطلحات موضوعية: |
0301 basic medicine, Cancer Research, Carcinogenesis, Apoptosis, Kaplan-Meier Estimate, Biology, medicine.disease_cause, Core Binding Factor beta Subunit, 03 medical and health sciences, Mice, 0302 clinical medicine, RNA interference, Stomach Neoplasms, Cell Line, Tumor, medicine, Biomarkers, Tumor, Gene silencing, Animals, Humans, Gene Silencing, 3' Untranslated Regions, Cell Proliferation, Regulation of gene expression, Gene knockdown, Competing endogenous RNA, RNA, Cell Cycle Checkpoints, Prognosis, Long non-coding RNA, Gene Expression Regulation, Neoplastic, Disease Models, Animal, MicroRNAs, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cancer research, Heterografts, RNA Interference, RNA, Long Noncoding |
| الوصف: |
Purpose: Long noncoding RNAs (lncRNAs) have emerged as important regulators in a variety of human diseases, including cancers. However, the overall biological roles and clinical significance of most lncRNAs in gastric carcinogenesis are not fully understood. We investigated the clinical significance, biological function, and mechanism of LINC01234 in gastric cancer. Experimental Design: First, we analyzed LINC01234 alterations in gastric cancerous and noncancerous tissues through an analysis of sequencing data obtained from The Cancer Genome Atlas. Next, we evaluated the effect of LINC01234 on the gastric cancer cell proliferation and apoptosis, and its regulation of miR-204-5p by acting as a competing endogenous RNA (ceRNA). The animal model was used to support the in vitro experimental findings. Results: We found that LINC01234 expression was significantly upregulated in gastric cancer tissues and was associated with larger tumor size, advanced TNM stage, lymph node metastasis, and shorter survival time. Furthermore, knockdown of LINC01234-induced apoptosis and growth arrest in vitro and inhibited tumorigenesis in mouse xenografts. Mechanistic investigations indicated that LINC01234 functioned as a ceRNA for miR-204-5p, thereby leading to the derepression of its endogenous target core-binding factor β (CBFB). Conclusions: LINC01234 is significantly overexpressed in gastric cancer, and LINC01234–miR-204-5p–CBFB axis plays a critical role in gastric cancer tumorigenesis. Our findings may provide a potential new target for gastric cancer diagnosis and therapy. Clin Cancer Res; 24(8); 2002–14. ©2018 AACR. |
| تدمد: |
1557-3265 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb897a2dc208a8018600265d68509b6
https://pubmed.ncbi.nlm.nih.gov/29386218 |
| حقوق: |
OPEN |
| رقم الأكسشن: |
edsair.doi.dedup.....dfb897a2dc208a8018600265d68509b6 |
| قاعدة البيانات: |
OpenAIRE |
