Switching From Reference Infliximab to Biosimilar CT-P13 Did Not Change Quality of Life in Stable Inflammatory Bowel Disease Patients
| العنوان: | Switching From Reference Infliximab to Biosimilar CT-P13 Did Not Change Quality of Life in Stable Inflammatory Bowel Disease Patients |
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| المؤلفون: | Klaas van der Linde, Michelle S G Sikkens, Yvonne J B van Megen, M. W. M. D. Lutgens, Joanne P J Bloemsaat-Minekus, Corinne M Stoop, Andrea Van Der Meulen, Halil Akol, Marieke Pierik, Johan Kuijvenhoven, Ids J. Klompmaker, Gerard Dijkstra |
| المساهمون: | Interne Geneeskunde, MUMC+: MA Maag Darm Lever (9), RS: NUTRIM - R2 - Liver and digestive health |
| المصدر: | Crohn's & Colitis 360, 4(3):001. Oxford University Press Crohn's & Colitis 360, 4(3). OXFORD UNIV PRESS |
| بيانات النشر: | Oxford University Press (OUP), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, business.industry, Gastroenterology, Biosimilar, EFFICACY, medicine.disease, THERAPY, Inflammatory bowel disease, CROHNS-DISEASE, Infliximab, quality of life, Quality of life, inflammatory bowel disease, Internal medicine, END-POINTS, medicine, biosimilar, INHIBITORS, infliximab, business, medicine.drug |
| الوصف: | Background Quality of life (QoL) data for patients with inflammatory bowel disease switched from the reference infliximab to biosimilar CT-P13 is lacking. This study aims to demonstrate noninferiority for QoL and efficacy after switching. Methods OoL and clinical efficacy were measured prior to and after 2, 4, and 6 CT-P13 infusions. Results One hundred seventy-eight patients were included. Noninferiority was established for QoL [ratio 97.95% (95% confidence interval 95.93 to 100.01)] and efficacy [difference −0.02 (95% confidence interval −0.68 to 0.64)]. Five patients reported 6 nonrelated, serious adverse events. Conclusions Switching from reference infliximab to CT-P13 did not affect the QoL or disease activity and was well tolerated. |
| وصف الملف: | application/pdf |
| تدمد: | 2631-827X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe906b4eebf52832318eaa05e6cf380 https://doi.org/10.1093/crocol/otab001 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....dfe906b4eebf52832318eaa05e6cf380 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2631827X |
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