التفاصيل البيبلوغرافية
العنوان:
8-Aryl xanthines potent inhibitors of phosphodiesterase 5
المؤلفون:
Gurdip Bhalay , David Beer , Stephen Paul Collingwood , Sarah Craig , Nicholas James Devereux , Rowan Stringer , Sandra Haberthuer , Trevor John Howe , Angela Glen , Katharine L. Turner , Andrew Dunstan , Heinz E. Moser , Ruth Arnold , Mauro Zurini , Sylvie Gomez , Paul Nicklin , Simon J. Watson , Urs Baettig , Reto Naef , David Andrew Sandham , Stephen Jelfs
المصدر:
Bioorganic & Medicinal Chemistry Letters . 12:2587-2590
بيانات النشر:
Elsevier BV, 2002.
سنة النشر:
2002
مصطلحات موضوعية:
Models, Molecular , Phosphodiesterase Inhibitors , Clinical Biochemistry , Pharmaceutical Science , Biochemistry , Isozyme , Chemical synthesis , chemistry.chemical_compound , Drug Discovery , medicine , Molecular Biology , chemistry.chemical_classification , Molecular Structure , biology , Phosphoric Diester Hydrolases , Chemistry , Organic Chemistry , Sulfonamide (medicine) , Xanthine , In vitro , Enzyme , Enzyme inhibitor , Xanthines , cGMP-specific phosphodiesterase type 5 , biology.protein , Molecular Medicine , medicine.drug
الوصف:
In clinical studies, several inhibitors of phosphodiesterase 5 (PDE5) have demonstrated utility in the treatment of erectile dysfunction. We describe herein a series of 8-aryl xanthine derivatives which function as potent PDE5 inhibitors with, in many cases, high levels of selectivity versus other PDE isoforms.
تدمد:
0960-894X
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dff42050bb668b5c21bf1217c7c6b8ce https://doi.org/10.1016/s0960-894x (02)00480-8
حقوق:
CLOSED
رقم الأكسشن:
edsair.doi.dedup.....dff42050bb668b5c21bf1217c7c6b8ce
قاعدة البيانات:
OpenAIRE
