MR spectroscopy of the liver – a reliable non-invasive alternative for evaluating non-alcoholic fatty liver disease
| العنوان: | MR spectroscopy of the liver – a reliable non-invasive alternative for evaluating non-alcoholic fatty liver disease |
|---|---|
| المؤلفون: | Lucian Mihai Florescu, Nicolae Cătălin Manea, Diana Rodica Tudoraşcu, Razvan Ene, A M Lăpădat, Ioana Andreea Gheonea, Daniel Pirici, Dan Ionuţ Gheonea |
| المصدر: | Romanian Journal of Morphology and Embryology |
| بيانات النشر: | Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | In vivo magnetic resonance spectroscopy, Adult, Male, Embryology, medicine.medical_specialty, Magnetic Resonance Spectroscopy, body mass index, Disease, Gastroenterology, Pathology and Forensic Medicine, chemistry.chemical_compound, Young Adult, Internal medicine, medicine, serum triglycerides, Humans, liver biopsy, Aged, Original Paper, medicine.diagnostic_test, Triglyceride, business.industry, Fatty liver, nutritional and metabolic diseases, non-alcoholic fatty liver disease, Non alcoholic, Cell Biology, General Medicine, Middle Aged, medicine.disease, digestive system diseases, chemistry, Liver, Liver biopsy, Inclusion and exclusion criteria, Female, non-alcoholic steatohepatitis, business, Body mass index, Developmental Biology |
| الوصف: | Non-alcoholic fatty liver disease (NAFLD) is one of the most common conditions worldwide that targets the liver parenchyma. NAFLD represents an intrahepatic triglyceride accumulation in the absence of excessive alcohol consumption and other diseases that affect the liver parenchyma. The current “gold standard” for evaluating the amount of intrahepatic fat is represented by liver biopsy, but many patients are reluctant and hardly accept undergoing this procedure due to its invasive nature. The current study addresses this aspect by evaluating the reliability of liver magnetic resonance spectroscopy (MRS) in diagnosing NAFLD, compared to the traditional invasive liver biopsy. The present study included a total of 38 patients based on several well-defined inclusion and exclusion criteria. We used the same NAFLD grading system for both liver MRS and liver biopsy: grade 0: 66% hepatocytes are affected. Regarding the NAFLD grade, over three-quarters of patients were classified as grade I and grade II, with a strong predilection for men. The current results indicated a significant association between the NAFLD grade indicated by liver MRS and the NAFLD grade indicated by liver biopsy. At the end of our study, we recommend using liver MRS for evaluating and grading NAFLD in association with other parameters like serum triglycerides and body mass index grade as this protocol can enhance early detection and provide an accurate grading that will lead to a proper management of this disease. |
| اللغة: | English |
| تدمد: | 2066-8279 1220-0522 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e003f03e4603d521699734295e2d2aab http://europepmc.org/articles/PMC7728118 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e003f03e4603d521699734295e2d2aab |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20668279 12200522 |
|---|