أعرض في EDS

Molecular basis for antiviral activity of two pediatric neutralizing antibodies targeting SARS-CoV-2 Spike RBD

التفاصيل البيبلوغرافية
العنوان: Molecular basis for antiviral activity of two pediatric neutralizing antibodies targeting SARS-CoV-2 Spike RBD
المؤلفون: Yaozong Chen, Jérémie Prévost, Irfan Ullah, Hugo Romero, Veronique Lisi, William D. Tolbert, Jonathan R. Grover, Shilei Ding, Shang Yu Gong, Guillaume Beaudoin-Bussières, Romain Gasser, Mehdi Benlarbi, Dani Vézina, Sai Priya Anand, Debashree Chatterjee, Guillaume Goyette, Michael W. Grunst, Ziwei Yang, Yuxia Bo, Fei Zhou, Kathie Béland, Xiaoyun Bai, Allison R. Zeher, Rick K. Huang, Dung N. Nguyen, Rebekah Sherburn, Di Wu, Grzegorz Piszczek, Bastien Paré, Doreen Matthies, Di Xia, Jonathan Richard, Priti Kumar, Walther Mothes, Marceline Côté, Pradeep D. Uchil, Vincent-Philippe Lavallée, Martin A. Smith, Marzena Pazgier, Elie Haddad, Andrés Finzi
المصدر: iScience. 26(1)
سنة النشر: 2022
مصطلحات موضوعية: Multidisciplinary
الوصف: Neutralizing antibodies (NAbs) hold great promise for clinical interventions against SARS-CoV-2 variants of concern (VOCs). Understanding NAb epitope-dependent antiviral mechanisms is crucial for developing vaccines and therapeutics against VOCs. Here we characterized two potent NAbs, EH3 and EH8, isolated from an unvaccinated pediatric patient with exceptional plasma neutralization activity. EH3 and EH8 cross-neutralize the early VOCs and mediate strong Fc-dependent effector activity
تدمد: 2589-0042
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0562d8ee692a297be811d153a249c3c
https://pubmed.ncbi.nlm.nih.gov/36514310
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....e0562d8ee692a297be811d153a249c3c
قاعدة البيانات: OpenAIRE
الوصف
تدمد:25890042