RGS14 expression in CA2 hippocampus, amygdala, and basal ganglia: Implications for human brain physiology and disease
| العنوان: | |
|---|---|
| المؤلفون: | Carolina Montanez‐Miranda, Sara N. Bramlett, John R. Hepler |
| المصدر: | Hippocampus. 33:166-181 |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Cognitive Neuroscience |
| الوصف: | RGS14 is a multifunctional scaffolding protein that is highly expressed within postsynaptic spines of pyramidal neurons in hippocampal area CA2. Known roles of RGS14 in CA2 include regulating G protein, H-Ras/ERK, and calcium signaling pathways to serve as a natural suppressor of synaptic plasticity and postsynaptic signaling. RGS14 also shows marked postsynaptic expression in major structures of the limbic system and basal ganglia, including the amygdala and both the ventral and dorsal subdivisions of the striatum. In this review, we discuss the signaling functions of RGS14 and its role in postsynaptic strength (long-term potentiation) and spine structural plasticity in CA2 hippocampal neurons, and how RGS14 suppression of plasticity impacts linked behaviors such as spatial learning, object memory, and fear conditioning. We also review RGS14 expression in the limbic system and basal ganglia and speculate on its possible roles in regulating plasticity in these regions, with a focus on behaviors related to emotion and motivation. Finally, we explore the functional implications of RGS14 in various brain circuits and speculate on its possible roles in certain disease states such as hippocampal seizures, addiction, and anxiety disorders. |
| تدمد: | 1098-1063 1050-9631 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0731f67e5af29985b98a20927d89e49 https://doi.org/10.1002/hipo.23492 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....e0731f67e5af29985b98a20927d89e49 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10981063 10509631 |
|---|